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首页> 外文期刊>Human psychopharmacology: clinical and experimental >Cognitive effects of long-term benzodiazepine use in older adults.
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Cognitive effects of long-term benzodiazepine use in older adults.

机译：长期使用苯二氮的认知效果在老年人。

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摘要

This study examined the potential for cognitive morbidity associated with the long-term use of benzodiazepine (BZ) sedative-hypnotics in a sample of healthy older adults. Tests of memory, attention and processing speed were conducted prior to and 1 month after drug discontinuation for 25 BZ-users and at similar intervals for 26 healthy control subjects. After controlling for differences in affective status between BZ-users and controls, there were no significant group differences in cognitive performance. However, BZ-users showed greater gains on tests of attention and speed of processing at repeat testing compared with controls this improvement was not attributable to a change in affective status. These findings suggest that there may be subtle and reversible effects of long-term BZ use on speed-dependent tasks in older adults. However, the magnitude of these effects is quite small and may be of little clinical significance in the healthy elderly.
机译：本研究调查了潜在的认知发病率与长期使用有关苯二氮(BZ)镇静催眠药样本的健康的老年人。进行了关注和处理速度之前和停药后1个月后25 BZ-users和类似的间隔为26个健康对照组。BZ-users之间的情感状态的差异和控制,没有明显的群体认知能力的差异。在测试BZ-users显示更大的收益在重复关注和处理速度测试与控制改善不是由于情感的变化的地位。微妙的和可逆的影响长期商务使用在老年人speed-dependent任务。然而,这些影响的大小相当小,可能是没有临床意义的在健康的老年人。

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