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首页> 外文期刊>Human psychopharmacology: clinical and experimental >Subjective assessment of the effects of CNS-active drugs on sleep by the Leeds sleep evaluation questionnaire: a review.
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Subjective assessment of the effects of CNS-active drugs on sleep by the Leeds sleep evaluation questionnaire: a review.

机译：主观评价的影响CNS-active药物对睡眠的利兹睡眠评估问卷调查:一个回顾。

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摘要

The Leeds sleep evaluation questionnaire (LSEQ) comprises ten self-rating 100 mm line analogue questions concerned with sleep and early morning behaviour. A literature search identified 83 studies in peer-reviewed journals that reported the use of the LSEQ for psychopharmacological investigations of drug effects on self-reported aspects of sleep. High internal consistency and reliability of the questionnaire have been demonstrated. Findings from studies involving a variety of psychoactive agents indicated that the LSEQ was able to quantify subjective impressions of sleep and waking and the effects of drugs in healthy volunteers, depressed and insomnia patients. In accordance with their known activity profile nocturnal administration of sedative hypnotic agents and antihistamines induced dose-related improvements in self-reported ease of getting to sleep, and quality of sleep but a decrease in alertness and behavioural integrity the following morning. Psychostimulants, on the other hand, impaired subjective ratings of sleep and increased early morning alertness. Antidepressants and certain anxiolytic agents improved both self-reported sleep aspects and early morning alertness. Treatment effects measured by the LSEQ corresponded to those measured for the same drugs by other assessment methods. These data indicate that the LSEQ is a robust and reliable instrument for psychopharmacological evaluations. Self-evaluations of sleep, as obtained by the LSEQ, can therefore provide consistent and meaningful measures for estimating the effectiveness of sleep modulators and sedative-hypnotic drugs.
机译：利兹睡眠评估问卷(LSEQ)由十个自我评定的100毫米线模拟问题关心睡眠,早晨的行为。在同行评审期刊上的研究报告使用LSEQ药理学调查毒品对自我报告的影响方面的睡眠。问卷的可靠性演示。各种各样的精神代理表示LSEQ能够量化主观印象睡眠和清醒和药物的影响健康的志愿者,抑郁和失眠病人。概要夜间镇静剂催眠剂和抗组胺药诱导剂量相关的改善自我放松让你睡觉的,睡但质量降低警觉性和行为的完整性第二天早上。另一方面,主观评级受损的睡眠,增加了清晨的警觉性。抗抑郁药物和某些抗焦虑的药物自我报告的睡眠方面和提高清晨的警觉性。由LSEQ对应的测量由其他评估测量相同的药物方法。健壮和可靠的工具药理学评价。自我评估的睡眠,如获得的LSEQ,因此可以提供一致的和有意义的估算办法睡眠调节器和的有效性镇静催眠药的药物。

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