A preliminary study of baclofen-induced growth hormone release in generalised social phobia.

Condren RM; Lucey JV; Thakore JH

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A preliminary study of baclofen-induced growth hormone release in generalised social phobia.

机译：baclofen-induced增长的初步研究激素释放普遍社交恐惧症。

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OBJECTIVE: The authors sought to examine central GABA(B) receptor responses in patients with generalised social phobia using the growth hormone (GH) response to baclofen. METHOD: Baclofen 20 mg was administered to 15 patients and 15 healthy matched controls and plasma growth hormone was monitored over a 3 h period. RESULTS: The GH response in patients was significantly reduced in comparison to that of controls when calculated as both area under the curve (AUC) and delta (Delta) response. CONCLUSIONS: The results suggest an abnormality of central GABA(B) receptor function in this disorder.

机译：目的:作者试图研究中心GABA受体(B)患者的反应普遍使用增长社交恐惧症激素对巴氯芬的回应。巴氯芬20毫克注射15例和15健康匹配控制和等离子体的增长激素是监控3 h段。GH响应明显的病人相比减少的控制的时候计算曲线下面积(AUC)三角洲(三角洲)反应。建议中央GABA (B)的异常受体功能障碍。

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来源
《Human psychopharmacology: clinical and experimental》 |2003年第2期|125-130|共6页
作者
Condren RM; Lucey JV; Thakore JH;
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作者单位

Neuroscience Department, St Vincent's Hospital, Richmond Road, Fairview, Dublin 3, Ireland.;

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原文格式 PDF
正文语种英语
中图分类药学;
关键词
Growth Hormone; Baclofen; Phobic DisordersGABA AgonistsHuman Growth Hormonegrowth hormone releaseArea Under CurveGeneralized social phobiagamma-Aminobutyric Acidprotein structure functionReceptor;

机译：生长激素;巴氯芬;恐惧症GABA激动剂人类生长激素生长激素释放曲线下面积广义性社交恐惧症γ-氨基丁酸蛋白结构功能受体;

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A preliminary study of baclofen-induced growth hormone release in generalised social phobia.

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