Zotepine in Huntington's disease.

Bonelli RM; Niederwieser G; Lahousen THofmann P

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Zotepine in Huntington's disease.

机译：Zotepine亨廷顿氏舞蹈症。

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The authors report a patient with Huntington's disease (HD) presenting with severe chorea. The motor scale of the unified HD rating scale (UHDRS-I) revealed 81 points. Motor function clearly improved with zotepine, until she reached an UHDRS-I of 34 points on day 7 of treatment. The patient was stable for at least 12 weeks. The improvement includes all seven categories of the UHDRS-I, especially chorea, gait and oral function. This is the first description of zotepine in HD. Our findings suggest that zotepine is useful in the treatment of HD chorea. Controlled trials of its use in HD would be welcome.

机译：作者报告杭丁顿氏症患者病(HD)出现严重舞蹈病。电动机的规模统一高清评定量表(UHDRS-I)显示81点。与zotepine明显改善,直到她达到了一个UHDRS-I 34分7天的治疗。病人稳定至少12周。改进包括所有的七大类UHDRS-I,特别是舞蹈病、步态和口腔函数。zotepine高清。zotepine是有用的治疗高清舞蹈病。对照试验中使用的高清受欢迎的。

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来源
《Human psychopharmacology: clinical and experimental》 |2003年第3期|227-229|共3页
作者
Bonelli RM; Niederwieser G; Lahousen THofmann P;
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作者单位

Department of Neurology and Psychiatry, Hospital BHB Eggenberg, Bergstrasse 27, A-8021 Graz, Austria. rm.bonelli@nextra.at;

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原文格式 PDF
正文语种英语
中图分类药学;
关键词
Chorea; Antipsychotic Agents; HDHuntington DiseaseZotepineDibenzothiepins;

机译：舞蹈病;抗精神病药;HDH亨廷顿病ZotepineDibenzothiepins;

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1. Hope in Huntington's disease A survey in counseling patients with Huntington's disease,as well as the caregivers [J] . Jerzy T Marcinkowski, Daniel Zielonka 中国神经再生研究（英文版） . 2009,第9期
2. Hope in Huntington＇s disease--survey in counseling patients with Huntington＇s disease, as well as the caregivers [J] . Jerzy T Marcinkowski, Daniel Zielonka 中国神经再生研究：英文版 . 2009,第9期
3. Selective separation, detection of zotepine and mass spectral characterization of degradants by LC-MS/MS/QTOF [J] . M.V.N. Kumar Talluri, Naveen Reddy Kandimalla, Raju Bandu, 药物分析学报（英文） . 2014,第002期
4. International Huntington Association and the World Federation of Neurology Research Group on Huntington's Chorea. Guidelines for the molecular genetics predictive test in Huntington's disease. [J] . journal of medical genetics . 1994,第7期

机译：International Huntington Association and the World Federation of Neurology Research Group on Huntington's Chorea. Guidelines for the molecular genetics predictive test in Huntington's disease.
5. Presymptomatic testing for Huntington's disease: a world wide survey. The World Federation of Neurology Research Group on Huntington's Disease. [J] . journal of medical genetics . 1993,第12期

机译：Presymptomatic testing for Huntington's disease: a world wide survey. The World Federation of Neurology Research Group on Huntington's Disease.
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Zotepine in Huntington's disease.

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