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首页> 外文期刊>BMJ: British medical journal >Effect of anti-inflammatory drugs on overall risk of common cancer: case-control study in general practice research database.
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Effect of anti-inflammatory drugs on overall risk of common cancer: case-control study in general practice research database.

机译：抗炎药对整体风险的影响一般常见的癌症:病例对照研究实践研究数据库。

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OBJECTIVE: To examine whether anti-inflammatory drug treatment protects against the commoner cancers in the United Kingdom. DESIGN: Case-control study using the general practice research database. SETTING: Practices throughout United Kingdom providing data to the database. SUBJECTS: Patients who had a first diagnosis of five gastrointestinal (oesophagus, stomach, colon, rectum, and pancreas) cancers and four non-gastrointestinal (bladder, breast, lung, and prostate) cancers in 1993-5 for whom prescription data were available for the at least the previous 36 months. Each case was matched for age, sex, and general practice with three controls. MAIN OUTCOME MEASURE: Risk of cancer. RESULTS: In 12 174 cancer cases and 34 934 controls overall risk of the nine cancers was not significantly reduced among those who had received at least seven prescriptions in the 13-36 months before cancer diagnosis (odds ratio 0.98, 95% confidence interval 0.89 to 1.07). Findings were nevertheless compatible with protective effects from anti-inflammatory drugs against cancers of the oesophagus (0.64, 0. 41 to 0.98), stomach (0.51, 0.33 to 0.79), colon (0.76, 0.58 to 1. 00), and rectum (0.75, 0.49 to 1.14) with dose related trends. The risk of pancreatic cancer (1.49, 1.02 to 2.18) and prostatic cancer (1.33, 1.07 to1.64) was increased among patients who had received at least seven prescriptions, but the trend was dose related for only pancreatic cancer. CONCLUSIONS: Anti-inflammatory drugs may protect against oesophageal and gastric cancer as well as colon and rectal cancer. The increased risks of pancreatic and prostatic cancer could be due to chance or to undetected biases and warrant further investigation.
机译：目的:检查是否抗炎药物治疗保护平民癌症在英国。病例对照研究使用惯例研究数据库。英国提供数据到数据库中。主题:第一诊断的患者五个胃肠道(食管、胃、结肠、直肠和胰腺癌症和四个non-gastrointestinal(膀胱癌、乳腺癌、肺癌和前列腺)癌症在1993 - 5的处方至少以前的数据是可用的36个月。和惯例和三个控制。结果测量:患癌症的风险。174癌症病例和34 934控制整体风险九个癌症没有明显的下降在那些收到了至少7处方13-36几个月前癌症诊断(优势比为0.98,95%的信心区间0.89 - 1.07)。然而兼容的保护作用从抗炎药物对癌症的食管(0.64 0。结肠(0.51,0.33,0.79),(0.76,0.58比1。00),直肠与剂量(0.75,0.49,1.14)相关的趋势。(1.49, 1.02, 2.18)和前列腺癌(1.33,1.07 to1.64)患者中增加收到至少七个处方,但趋势是只有胰腺剂量相关癌症。预防食道癌和胃癌结肠癌和直肠癌。胰腺和前列腺癌的风险由于机会或未被发现的偏差和保证进一步调查。

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