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首页> 外文期刊>BMJ: British medical journal >Paralytic poliomyelitis associated with live oral poliomyelitis vaccine in child with HIV infection in Zimbabwe: case report.
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Paralytic poliomyelitis associated with live oral poliomyelitis vaccine in child with HIV infection in Zimbabwe: case report.

机译：麻痹性脊髓灰质炎与生活口语脊髓灰质炎疫苗与艾滋病毒感染孩子在津巴布韦:病例报告。

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摘要

OBJECTIVE: To describe a complication of oral vaccination with live, attenuated poliomyelitis virus in a child infected with HIV. DESIGN: Case report. SETTING: Teaching hospital in Harare, Zimbabwe. SUBJECTS: A boy of 41/2 years and his mother. MAIN OUTCOME MEASURES: Results of clinical and laboratory investigations. RESULTS: Two weeks after receiving the second dose of oral poliomyelitis vaccine during national immunisation days the child developed paralysis of the right leg. He had a high titre of antibodies against poliovirus type 2, as well as antibodies against HIV-1, a low CD4 count, a ratio of CD4 to CD8 count of 0.47, and hypergammaglobulinaemia. He did not have any antibodies against diphtheria, tetanus, or poliovirus types 1 and 3, although he had been given diphtheria, tetanus, and pertussis and oral polio vaccines during his first year and a booster of the diphtheria, tetanus, and pertussis vaccine at 24 months. He had no clinical symptoms of AIDS, but his mother had AIDS and tuberculosis. CONCLUSION: Paralytic poliomyelitis in this child with HIV infection was caused by poliovirus type 2 after oral poliomyelitis vaccine.
机译：目的:描述一个口头的并发症接种活减毒脊髓灰质炎病毒在儿童感染艾滋病毒。报告。津巴布韦。妈妈。临床和实验室调查。两周后收到第二个剂量的口服脊髓灰质炎疫苗在国家免疫天孩子发达瘫痪的右腿。2型脊髓灰质炎病毒的抗体,以及hiv - 1抗体,CD4细胞计数较低CD4, CD8计数的比率是0.47,hypergammaglobulinaemia。抗体白喉、破伤风、或1型和3型脊髓灰质炎病毒,不过他鉴于白喉、破伤风、百日咳和口腔在他的第一年和脊髓灰质炎疫苗升压的白喉、破伤风和百日咳疫苗在24个月。艾滋病和艾滋病,但他的母亲肺结核。与艾滋病毒感染是由这个孩子口服脊髓灰质炎后2型脊髓灰质炎病毒疫苗

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