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首页> 外文期刊>BMJ: British medical journal >The Norwegian naturalistic treatment study of depression in general practice (NORDEP)-I: randomised double blind study.
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The Norwegian naturalistic treatment study of depression in general practice (NORDEP)-I: randomised double blind study.

机译：挪威自然治疗的研究抑郁症一般实践(NORDEP)我:随机双盲研究。

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OBJECTIVE: To evaluate the efficacy of emotional support and counselling combined with placebo or antidepressants with single or dual mechanism of action in the treatment of depression in primary care. DESIGN: Randomised double blind study. SETTING: Several locations in Norway. SUBJECTS: 372 patients with depression. MAIN OUTCOME MEASURES: Improvement (clinical remission) reported both by the patient (Montgomery Asberg depression rating scale) and the physician (clinical global improvement and impression scales). RESULTS: Intention to treat analyses showed 47% remission in patients randomised to placebo compared with 61% remission in patients randomised to sertraline (odds ratio 0.56, 95% confidence interval 0.33 to 0.96) and 54% in patients randomised to mianserin (0.75, 0.44 to 1.27). Women responded better than men (1.86, 1.17 to 2.96). Subgroup analyses showed that subjects with recurrent depression (n=273) responded more frequently to sertraline than to placebo (0.43, 0.23 to 0.82) than those having their first episode of depression (1.18, 0.39 to 3.61). Statistically significant interactions between type of drug treatment and history of depression were not shown by logistic regression. CONCLUSION: The combination of active drug and simple psychological treatment (counselling, emotional support, and close follow up over a 24 week period) was more effective than simple psychological treatment alone, in particular for those with recurrent depression. Overall, women may benefit more than men. If confirmed in future studies, the findings should lead to more differentiated treatment guidelines for depression in primary care.
机译：目的:评估情绪的功效支持和咨询与安慰剂或相结合抗抑郁药与单或双机制治疗抑郁症的主要行动护理。设置:挪威的几个地方。372抑郁症患者。措施:改进(临床缓解期)根据患者(蒙哥马利Asberg报道抑郁量表)和医生(临床全球改善和印象尺度)。在病人随机显示,47%缓解安慰剂缓解的病人比例为61%随机舍曲林(优势比为0.56,95%置信区间0.33 - 0.96)和54%病人随机米安色林(0.75,0.441.27)。1.17到2.96)。主题与复发性抑郁症(n = 273)更频繁地回应舍曲林比安慰剂(0.43,0.23,0.82)比他们的首发抑郁症(1.18,0.393.61)。类型的药物治疗和历史之间的关系抑郁症并非逻辑回归所示。结论:活性药物的组合简单的心理治疗(咨询,情感支持,密切跟进24周)是比简单的更有效心理治疗,特别是复发性抑郁症。比男人更可能受益。研究中,研究结果应导致更多分化治疗指南抑郁症在初级保健。

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