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首页> 外文期刊>BMJ: British medical journal >Pertussis vaccination and wheezing illnesses in young children: prospective cohort study. The Longitudinal Study of Pregnancy and Childhood Team.
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Pertussis vaccination and wheezing illnesses in young children: prospective cohort study. The Longitudinal Study of Pregnancy and Childhood Team.

机译：百日咳疫苗接种和喘息的疾病幼儿:前瞻性队列研究。怀孕和童年的纵向研究团队。

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OBJECTIVES: To examine the relation between pertussis vaccination and the prevalence of wheezing illnesses in young children. DESIGN: Prospective cohort study. SETTING: Three former health districts comprising Avon Health Authority. SUBJECTS: 9444 of 14 138 children enrolled in the Avon longitudinal study of pregnancy and childhood and for whom data on wheezing symptoms, vaccination status, and 15 environmental and biological variables were available. MAIN OUTCOME MEASURES: Episodes of wheezing from birth to 6 months, 7-18 months, 19-30 months, and 31-42 months. These time periods were used to derive five categories of wheezing illness: early wheezing (not after 18 months); late onset wheezing (after 18 months); persistent wheezing (at every time period); recurrent wheezing (any combination of two or more episodes for each period); and intermittent wheezing (any combination of single episodes of reported wheezing). These categories were stratified according to parental self reported asthma or allergy. RESULTS: Unadjusted comparisons of the defined wheezing illnesses in vaccinated and non-vaccinated children showed no significant association between pertussis vaccination and any of the wheezing outcomes regardless of stratification for parental asthma or allergy. Wheeze was more common in non-vaccinated children at 18 months, and there was a tendency for late onset wheezing to be associated with non-vaccination in children whose parents did not have asthma, but this was not significant. After adjustment for environmental and biological variables, logistic regression analyses showed no significant increased relative risk for any of the wheezing outcomes in vaccinated children: early wheezing (0.99, 95% confidence interval 0.80 to 1.23), late onset wheezing (0.85, 0.69 to 1.05), persistent wheezing (0.91, 0.47 to 1.79), recurrent wheezing (0.96, 0.72 to 1.26), and intermittent wheezing (1.06, 0.81 to 1.37). CONCLUSIONS: No evidence was found that pertussis vaccination increases the risk of wheezing illnesses in young children. Further follow up of this population with objective measurement of allergy and bronchial responsiveness is planned to confirm these observations.
机译：目的:研究之间的关系百日咳疫苗接种和普遍的气喘儿童的疾病。前瞻性群组研究。卫生区包括雅芳的健康权威。加入雅芳的纵向研究怀孕和童年和数据为谁喘息症状,免疫状态和15环境和生物变量可用。气喘吁吁的从出生到6个月,7 - 18个月,19-30月,31-42月。时间被用来推导五类气喘病:早期喘息(不经过18个月);持续喘息(在每个时间段);反复喘息(两个或两个的任意组合更集每段);喘息(单集的任意组合报道喘息)。根据父母的自我报告的分层哮喘或过敏。定义气喘疾病的比较没有接种疫苗和孩子没有显示重要联系百日咳疫苗接种和任何喘息的结果不管父母的哮喘的分层或过敏。未接种的孩子18个月,是一个倾向于晚发型喘息与non-vaccination的孩子父母没有哮喘,但这不是有很重要的意义。和生物变量、逻辑回归分析显示,相对无显著增加任何喘息的结果的风险接种疫苗的儿童:早期喘息(0.99、95%置信区间0.80 - 1.23),晚发型喘息(0.85,0.69,1.05),持久的喘息(0.91,0.47,1.79),反复喘息(0.96, 0.72, 1.26),断断续续的喘息(1.06, 0.81, 1.37)。发现百日咳疫苗接种增加在儿童哮喘疾病的风险。这个人口的进一步跟进客观的测量过敏和支气管反应计划来确认这些观察。

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