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首页> 外文期刊>Journal of the American Animal Hospital Association >The Renal Effects of NSAIDs in Dogs
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The Renal Effects of NSAIDs in Dogs

机译：非甾体抗炎药的肾影响狗

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摘要

The quality of life for dogs with osteoarthritis can often be improved with nonsteroidal anti-inflammatory drugs (NSAIDs); however, the number of adverse drug events associated with NSAID use reported to the Federal Drug Administration Center for Veterinary Medicine is higher than that for any other companion animal drug. Of those events, adverse renal reactions are the second most reported. NSAIDs produce pharmacologic effects via inhibition of cyclooxygenase (COX), which decreases production of prostanoids. Prostaglandins are synthesized by both the COX-1 and COX-2 enzymes in the healthy kidney and influence renal blood flow, glomerular filtration rate, renin release, and Na excretion. There are important species differences in the renal expression of COX-1 and COX-2. For example, dogs have higher basal levels of COX-2 expression in the kidney compared with humans. In addition, in dogs with chronic kidney disease, an increase in COX-2 expression occurs and synthesis of prostaglandins shifts to the COX-2 pathway. For those reasons, NSAIDs that target COX-2 may be expected to adversely affect renal function in dogs, especially dogs with chronic kidney disease. The purpose of this review was to evaluate the literature to report the renal effects of NSAIDs in dogs.
机译：骨关节炎的狗的生活质量与非甾体类通常可以改善抗炎药(非甾体抗炎药);数量的药物不良事件联系在一起非甾体抗炎药使用报告给联邦药物管理中心的兽医高于其他同伴动物药物。是第二个最报道。药物通过抑制效果环氧合酶(COX),减少生产前列腺素类。COX-1和cox - 2酶的健康影响肾脏和肾血流量,肾小球滤过率,肾素释放,钠排泄。有重要的物种差异肾COX-1和cox - 2的表达。狗有更高的基底的cox - 2表达水平与人类相比,肾。在狗与慢性肾脏疾病,增加cox - 2表达和合成的发生前列腺素转向cox - 2通路。cox - 2可能是这些原因,非甾体抗炎药这一目标将影响肾功能狗狗,尤其是慢性肾脏疾病。评估文献报告肾非甾体抗炎药在狗的影响。

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