首页> 外文期刊>Journal of the American Animal Hospital Association >Urinary Aldosterone/Creatinine Ratio After Fludrocortisone Suppression Consistent with PHA in a Cat
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Urinary Aldosterone/Creatinine Ratio After Fludrocortisone Suppression Consistent with PHA in a Cat

机译:尿醛固酮/肌酐比值氟氢可的松抑制与PHA一致在一只猫

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摘要

A 9 yr old cat was presented with clinical signs and laboratory abnormalities attributed to arterial hypertension (mean systolic arterial pressure, 290 mm Hg). Plasma aldosterone concentration was increased at the time of admission (651 pmol/L), but serum creatinine and potassium concentrations were within the reference range. A second increased aldosterone (879 pmol/L) and normal plasma renin activity (1.85 ng/mL/hr) resulted in an increased aldosterone/renin ratio, which was suggestive of primary hyperaldosteronism (PHA). To further support the diagnosis of PHA, the urinary aldosterone/creatinine ratio was calculated both before and after oral administration of fludrocortisone acetate (0.05 mg/kg q 12 hr for 4 consecutive days). The urinary aldosterone/creatinine ratio was 92.6 x 10(-9) before fludrocortisone administration and 155.8 x 10(-9) 4 days later. Absence of suppression was typical of PHA. The cat had a limited response to antihypertensive medication and died before treatment for PHA could be instituted. A necropsy was not permitted by the owner.
机译:一个9岁的猫被授予临床症状和实验室异常原因动脉高血压(平均收缩期动脉压力,290毫米汞柱)。浓度增加的时候承认(651 pmol / L),但血清肌酐和中钾浓度参考范围。(879 pmol / L)和正常血浆肾素活性(1.85 ng / mL / hr)导致了增加醛固酮/肾素比,这是暗示主要高醛甾酮症(PHA)。PHA的诊断,尿的支持醛固酮/肌酐比率计算之前和之后的口服醋酸氟氢可的松(0.05毫克/公斤问12人力资源4连续两天)。醛固酮/肌酐比值为92.6 x 10 (9)氟氢可的松前政府和155.8 x10(9) 4天后。典型的PHA。抗高血压药物和死亡治疗PHA可以制定。被老板不允许。

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