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首页> 外文期刊>Journal of endometriosis and pelvic pain disorders. >Role of bacterial contamination in endometriosis
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Role of bacterial contamination in endometriosis

机译：子宫内膜异位的细菌污染的作用

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摘要

The human lower genital tract is constantly exposed to various microorganisms, which can infect the upper genital tract through ascending migration. We report on tests of the hypothesis that as normal microbial flora in the vagina, some gram-negative bacteria infect the uterine wall after ascending migration from the vagina, to contaminate menstrual blood, consequently resulting in accumulation of endotoxin in the menstrual/peritoneal fluid and initiation of pelvic inflammation. The aim of the present review is to assess possible intrauterine microbial colonization and to examine the stimulatory effect of E. co//-derived lipopolysaccharide (LPS) on the secretion of various macromolecules by macrophages (Mcf)) known to be involved in endometriosis. We also assess the growth-promoting effect of LPS on endometrial cells and the role of Toll-like receptor 4 (TLR4), a receptor recognizing LPS, in the secretion of macromolecules by M(j) and growth of endometrial cells. We found higher intrauterine microbial colonization in women with endometriosis than in controls. The ligand from gram-negative bacteria is involved in TLR4-mediated proinflammation in the pelvis as well as growth of endometriosis. Treatment with gonadotropin-releasing hormone agonist (GnRHa) further promotes intrauterine microbial colonization compared with GnRHa-untreated women.Conclusions: We propose the bacterial contamination hypothesis as a new concept in endometriosis. Based on our current findings, an estrogen-suppressing agent and an antimicrobial agent may have new therapeutic potential in women with endometriosis.
机译：人类不断低生殖道可以接触到各种微生物通过提升上生殖道感染迁移。正常的阴道微生物菌群,一些革兰氏阴性细菌感染子宫墙从阴道上行迁移后,因此污染经血导致内毒素的积累月经/腹水和启动盆腔炎症。评估是评估可能的子宫内微生物定殖和检查刺激大肠有限公司/ /派生的效果脂多糖(LPS)的分泌各种大分子的巨噬细胞(Mcf)。)参与子宫内膜异位。评估有限合伙人的促生长效应子宫内膜细胞和toll样的作用受体4 (TLR4)受体识别有限合伙人大分子的分泌M (j)子宫内膜细胞的生长。在女性子宫内的微生物殖民子宫内膜异位比控制。革兰氏阴性细菌参与TLR4-mediated proinflammation在骨盆子宫内膜异位的生长。促性腺激素释放激素激动剂(GnRHa)进一步促进子宫内的微生物殖民与GnRHa-untreated相比女性。污染假说作为一个新概念子宫内膜异位症。estrogen-suppressing代理和抗菌素代理可能会有新的治疗潜在的女性子宫内膜异位。

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