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首页> 外文期刊>Journal of endometriosis and pelvic pain disorders. >A preliminary communication: ongoing study on HOXA10 methylation profile of endometriosis patients with infertility
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A preliminary communication: ongoing study on HOXA10 methylation profile of endometriosis patients with infertility

机译：初步交流:正在进行的研究子宫内膜异位症HOXA10甲基化的状况不孕不育患者

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摘要

Background: Endometriosis and infertility have been shown to be related to one another. The mechanisms that explain this phenomenon are not fully understood. One of the possible mechanisms of infertility in endometriosis patients is failure of implantation of the embryo in the endometrium. This may be caused by high levels of methylation of HOXA10 gene in patients with endometriosis, resulting a decrease in the expression of genes that play a role in this endometrial receptivity. Objective: To determine the methylation profile of HOXA10 gene on eutopic endometrium in endometriosis patients with infertility. Methods: This is a cross-sectional study conducted at Cipto Mangunkusumo General Hospital from July 2015 to July 2016. The subjects of research were cystic ovarian endometriosis patients with infertility, confirmed histo-pathologically and non-endometriosis-fertile patients. The methylation status of HOXA 10 gene in both groups was examined and compared. Statistical analysis is Mann-Whitney U-test, a two-tailed p value less than 0.05 was considered significant.
机译：背景:子宫内膜异位症、不孕症是互相关联的。机制,解释这一现象完全理解。子宫内膜异位症不孕的患者的胚胎植入的失败子宫内膜。在患者HOXA10基因的甲基化子宫内膜异位,从而减少表达的基因发挥作用子宫内膜接受。HOXA10基因的甲基化剖面位置正常的在子宫内膜异位症患者子宫内膜不孕。研究Cipto Mangunkusumo将军医院从2015年7月到2016年7月。课题的研究是囊性卵巢子宫内膜异位症不孕患者,确诊histo-pathologically和non-endometriosis-fertile病人。在两组HOXA 10基因的甲基化状态研究和比较。是Mann-Whitney紫外线测试,小动物——一张长有p值更少比0.05被认为是显著的。

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