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首页> 外文期刊>Journal of endometriosis and pelvic pain disorders. >Evaluating CA125 and VAS pain modifications following GnRH analog to exclude superficial endometriosis as cause of chronic pelvic pain
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Evaluating CA125 and VAS pain modifications following GnRH analog to exclude superficial endometriosis as cause of chronic pelvic pain

机译：评估CA125和血管疼痛的修改后促模拟排除肤浅子宫内膜异位引起的慢性骨盆疼痛

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Background: The study aim was to assess the reliability in the diagnosis of superficial endometriosis of the combined evaluation of 2 parameters: modifications of serum CA125 and VAS pain score following 1 dose of GnRH analog (GnRH-a).Methods: Women with chronic pelvic pain (CPP) were managed by GnRH-a administration and diagnostic lap-aroscopy. Serum CA125 and VAS pain score were assessed for each patient at the early follicular phase and 2 months after the administration of 11.25 mg GnRH-a. Following laparoscopy, subjects were grouped into groups A (72 women with endometriosis) and B (46 women without endometriosis). A multivariate model for CA125 and VAS reduction and for the combination of the 2 markers was calculated using logistic regression and diagnostic performance was evaluated as the AUC of ROC curve. Main outcome measure was the accuracy of the modifications of serum CA125 levels and VAS score following GnRH-a, in patients with histological diagnosis of superficial endometriosis.Results: At baseline, both groups showed similar CA125 levels and VAS scores. Two months after GnRH-a, a significant reduction (delta [A]) in CA125 levels and VAS pain score was observed in group A only. AUCs for ACA125, AVAS score and for combination of these 2 deltas were 0.90, 0.83 and 0.97, respectively. Conclusions: The assessment of serum CA125 and VAS pain score following GnRH-a demonstrates good reliability to exclude superficial endometriosis in patients with CPP. The response to GnRH-a administration in these women could therefore be employed as an ex juvantibus criterion for endometriosis diagnosis.
机译：背景:该研究的目的是评估可靠性诊断的肤浅子宫内膜异位的组合评价2参数:血清CA125和脉管的修改疼痛评分后1剂量的促模拟(GnRH-a)。(CPP)是由GnRH-a管理和管理诊断lap-aroscopy。分数为每个病人在早期评估卵泡期和2个月后11.25毫克GnRH-a管理工作。腹腔镜检查,实验对象被分成组(72女性子宫内膜异位症)和B(46名女性没有子宫内膜异位)。CA125和减少血管和组合2标记计算使用的物流回归和诊断性能评估的AUC ROC曲线。测量的准确性的修改血清CA125水平和脉管得分GnRH-a,患者的组织学诊断表面的子宫内膜异位症。两组基线,显示出类似的CA125水平和脉管分数。显著减少(δ[A]) CA125水平和血管疼痛分数只在A组。ACA125 auc,艾娃得分和组合这两个三角洲的0.90、0.83和0.97,分别。血清CA125和脉管GnRH-a后疼痛评分展示了良好的可靠性排除肤浅的子宫内膜异位症患者的CPP。响应GnRH-a政府在这些女人可以是前女友子宫内膜异位症诊断juvantibus标准。

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