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首页> 外文期刊>Infectious diseases in clinical practice: IDCP >Chronic Exposure of the Blood-Brain Barrier to Highly Active Antiretroviral Therapy Potential Consequences on the CNS
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Chronic Exposure of the Blood-Brain Barrier to Highly Active Antiretroviral Therapy Potential Consequences on the CNS

机译：慢性接触的血脑屏障高活性抗逆转录病毒疗法的潜力影响中枢神经系统

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摘要

Typical presentation of human immunodeficiency virus (HlV)-associated central nervous system (CNS) involvement is quite variable and can include cognitive deficits in memory and information processing, mild motor dysfunctions, or frank dementia. In the mid-1990s, HIV patients with cognitive impairments were responsive to triple therapy resulting in significant improvement in survival. Mortality among patients with CD4 counts of <100/mm~3 dropped from 35/100 person-years in 1993 to 10/100 person-years in 1997. Currently, approximately 15% to 20% of HIV patients present clinically with acute or subacute focalized CNS involvement related to opportunistic infections and neoplasms. In addition, 30% to 40% of AIDS patients develop opportunistic infections of the CNS during the course of their disease. Supporting these observations, our autopsy findings between 1985-2000 report that of 483 AIDS cases, 27% had HIV encephalitis (HIVE), 22% had cytomegalovi-rus encephalitis, 2.5% had toxoplasmosis, 5% had fungal infections, 3% had progressive multifocal leukoencephalop-athy, and 9% had non-Hodgkin's lymphoma.
机译：人类免疫缺陷的典型表现病毒(HlV)相关的中枢神经系统(中枢神经系统)的参与是非常变量,可以包括记忆和认知障碍信息处理、温和的运动障碍,弗兰克或痴呆。有认知障碍的回应三联疗法导致显著改善生存。与CD4计数< 100 /毫米~ 3降至35/100人年到1993年的10/100人每年1997. 患者出现临床急性或亚急性针对性相关的中枢神经系统的参与机会性感染和肿瘤。此外,30%到40%的艾滋病患者机会性感染的中枢神经系统的疾病。观察,我们解剖结果之间1985 - 2000年报告的483例艾滋病病例,27%艾滋病毒脑炎(蜂窝),22%有cytomegalovi-rus脑炎、弓形体病了2.5%,5%真菌感染,3%有渐进多焦点的有非霍奇金leukoencephalop-athy, 9%淋巴瘤。

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