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首页> 外文期刊>Journal of basic and clinical physiology and pharmacology >Erythrina (ysjstemon-derived flavonoids account only In part for the plant's specific effects on rat uterus and vagina
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Erythrina (ysjstemon-derived flavonoids account only In part for the plant's specific effects on rat uterus and vagina

机译：刺桐(ysjstemon-derived黄酮类化合物帐户只在部分植物的具体影响大鼠子宫和阴道

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Background: The stem bark ethyl acetate extract of Erythrina lysistemon was found to induce vaginal proliferation in ovariectomized rats orally treated. Alpinumisoflavone (AIF) and abyssinone V-4'-methyl-ether (AME), isolated as its major constituents, were reported to separately provoke uterine growth and/or vaginal proliferation. The present study aimed at evaluating the effects of the mixture of AIF and AME (51 mg/kg [AIF]+153 mg/kg [AME]) following their relative abundance in the extract, in order to compare these effects to those off. lysistemon. Methods: The study was performed in ovariectomized rats treated intraperitoneally for 3 days. Estradiol valerate (E2V) and AME were used for positive controls. Morphological and histological changes of animals' uterus and vagina were used as the hallmark of estrogenicity. Results: E. lysistemon extract induced estrogen-like effects only on the uterus and significantly increased uterine wet weight (p<0.01) and uterine epithelial height (p<0.01). These results suggest a tissue-selective action of ￡. lysistemon extract depending on the route of administration. The mixture of AIF and AME induced E. lysistemon-like effects only at a dose of 1 mg/kg BW/d (0.25 mg/kg+0.75 mg/kg), although these effects were lower in magnitude (p<0.05) compared to those induced by E. lysistemon extract. Conclusions: Effects induced by the mixture of AIF and AME are analogous to those of E. lysistemon, but the low magnitude of these effects suggests that there are minor metabolites that interact with AIF and AME to provoke the specific effects of E. lysistemon.
机译：背景:茎皮乙酸乙酯提取的刺桐lysistemon发现引起阴道扩散在切除卵巢的老鼠口服V-4甲基醚(AME),孤立作为其主要的成分,据报道单独挑起子宫增长和/或阴道扩散。本研究旨在评估的影响如果和AME的混合物(51个毫克/公斤(AIF) + 153毫克/公斤(AME))之后,他们的相对丰度在提取,为了比较这些影响那些了。在切除卵巢的老鼠进行治疗腹腔内3天。(E2V)和AME用于积极控制。形态学和组织学的变化用作动物的子宫和阴道求偶性的标志。只有在提取诱发类似雌激素的作用子宫和显著增加子宫湿体重(p < 0.01)和子宫上皮高度(p < 0.01)。tissue-selective￡。这取决于给药途径。如果和AME的混合物诱导大肠lysistemon-like效果只在一剂1毫克/公斤体重/天(0.25毫克/公斤+ 0.75毫克/公斤),尽管这些效果低幅度相比(p < 0.05)引起大肠lysistemon提取。如果和AME引发的影响类似于这些的大肠lysistemon,但低这些效应表明,级轻微的代谢物,如果和互动AME惹E的具体影响。lysistemon。

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