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首页> 外文期刊>Journal of basic and clinical physiology and pharmacology. >Comparative assessment of onion and garlic extracts on endogenous hepatic and renal antioxidant status in rat
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Comparative assessment of onion and garlic extracts on endogenous hepatic and renal antioxidant status in rat

机译：洋葱和大蒜的比较评估提取内生肝和肾在大鼠抗氧化状态

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摘要

Background: Despite growing claims of functional health benefits in folkloric medicine, the safety of chronic/ elevated intakes of onion and garlic cannot be assumed. Therefore, this study assesses oral administration of varied doses of onion and garlic on some biomarkers of hepatic and renal functions in rats. Methods: Animals were divided into five groups: control group received vehicle and extract-treated groups received varied doses of onion or garlic extract (0.5 mL and 1.0 mL/100 g bwt/day) for 6 weeks. Results: Both doses of onion caused marked (p<0.05) increase in hepatic and renal levels of glutathione (GSH), glutathione S-transferase (GST), superoxide dismutase (SOD), catalase (CAT) and marked (p<0.05) decrease in malondialdehyde (MDA). Treatment with low dose of garlic elicited similar trend except in hepatic CAT, renal SOD and GST levels. A high dose of garlic only caused marked (p<0.05) increase in hepatic GST, renal GST, and SOD. Both doses of onion and low dose of garlic significantly (p<0.05) enhanced renal Na~+/K~+-ATPase activity. Only a high dose of onion caused significant (p<0.05) increase in hepatic aspartate transaminase (AST), alkaline phosphatase (ALP), and decrease in plasma AST activities.
机译：背景:尽管越来越多的功能安全健康的医学慢性/高摄入量的洋葱和大蒜不能承担。口服不同剂量的洋葱大蒜在一些生物标记的肝和肾功能的老鼠。分成5组:对照组收到车辆和extract-treated组收到不同的剂量洋葱或大蒜萃取物(0.5毫升和1.0毫升/ 100g bwt /天)为6周。洋葱在肝引起显著增加(p < 0.05)和肾功能水平的谷胱甘肽(GSH),谷胱甘肽S-transferase (GST),过氧化物歧化酶(SOD)、过氧化氢酶(CAT)和明显降低(p < 0.05),丙二醛(MDA)。治疗低剂量的大蒜了类似的趋势除了猫肝,肾SOD和销售税的水平。肝销售税增加显著(p < 0.05),肾销售税和草皮。大蒜显著(p < 0.05)提高肾Na ~ + / K ~ + atp酶活性。洋葱导致显著增加(p < 0.05)肝天冬氨酸转氨酶(AST)、碱性磷酸酶(ALP)、降低血浆AST活动。

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