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首页> 外文期刊>Journal of basic and clinical physiology and pharmacology. >Antioxidant, antinociceptive and anti-inflammatory properties of the aqueous and ethanolic leaf extracts of Andrographis paniculata in some laboratory animals
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Antioxidant, antinociceptive and anti-inflammatory properties of the aqueous and ethanolic leaf extracts of Andrographis paniculata in some laboratory animals

机译：抗氧化剂,antinociceptive和消炎水和ethanolic叶的属性提取的穿心莲香实验动物

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Background: The study was designed to evaluate the anti-inflammatory, analgesic and antioxidant properties of Andrographis paniculata leaf extracts in laboratory animals.Methods: The dried and powdered leaves of the plant were subjected to phytochemical and proximate analyses. Its mineral content was also determined. Acute toxic-ity experiments were first performed to determine a safe dose level. The plant material was extracted using water and ethanol as solvents. These extracts were then used to test for the anti-inflammatory, analgesic and antioxidant properties of the plant. The anti-inflammatory tests included carrageenan-induced and histamine-induced paw oedema. The analgesic tests conducted were formalin paw lick test and acetic acid writhing test. The antioxidant activities of the extracts of A paniculata were determined by l,l-diphenyl-2-picrylhydrazyl (DPPH), ferric reducing antioxidant power (FRAP), total polyphenol (TP) and 2,2/-azinobis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS) using ascorbic acid as standard for both DPPH and FRAP, and gallic acid as a standard for both TP and ABTS.
机译：背景:研究旨在评估抗炎、镇痛和抗氧化剂穿心莲香叶子的属性在实验室动物身上提取。和叶子的植物受到粉植物化学的和近似分析。矿物质含量也决定。toxic-ity实验首次演出确定一个安全的剂量水平。使用水和乙醇作为提取吗溶剂。抗炎、镇痛和植物的抗氧化性能。抗炎测试包括carrageenan-induced和histamine-induced爪子水肿。福尔马林爪子舔测试和醋酸扭动测试。香的测定l, l-diphenyl-2-picrylhydrazyl (DPPH),铁降低抗氧化能力(收紧),总数茶多酚(TP)和2、2 / -azinobis-3-ethylbenzothiazoline-6-sulfonic酸(abt)使用抗坏血酸作为标准DPPH和收紧,和没食子酸为标准TP和abt。

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