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首页> 外文期刊>MIMS Doctor. >Achieving sustained RA remission with an oral JAK inhibitor in a patient with MTX intolerance and comorbidities
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Achieving sustained RA remission with an oral JAK inhibitor in a patient with MTX intolerance and comorbidities

机译：实现持续的RA与口服木菠萝缓解抑制剂在患者MTX偏狭并发症

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A 60-year-old man with hypertension and hyperlipidaemia presented with active arthritis, prominent synovitis in the metacarpophalangeal (MCP) joints and effusion in both knees. He also complained of early morning stiffness lasting about an hour every day. Prior to presentation at our rheumatology clinic in December 2017, the patient was treated with methotrexate (MTX) 20 mg QW when first diagnosed with rheumatoid arthritis (RA) in 2013-2014 at a centre in mainland China. He was later switched to leflunomide 20 mg QD plus prednisolone 15 mg QD in December 2014 when he was found to have developed rheumatoid nodules possibly induced by MTX. As the patient achieved only moderate disease control with leflunomide plus prednisolone, biologic therapy was advised, to which the patient refused due to fear of injections. He was continued on leflunomide and prednisolone since then and the rheumatoid nodules gradually decreased in number and size.
机译：与高血压和一个60岁的老男人hyperlipidaemia呈现活跃的关节炎,突出在掌指的滑膜炎(MCP)在两膝盖关节和积液。抱怨早晨刚度持久每天大约一个小时。我们的风湿病学诊所2017年12月,病人接受甲氨蝶呤(MTX) 20毫克QW当第一诊断为风湿性关节炎(RA)在2013 - 2014年在Mainland China中心。他后来转向leflunomide 20毫克QD2014年12月+强的松15毫克QD他被发现有发达的类风湿结节可能引起MTX。只有与leflunomide温和的疾病控制+强的松,生物治疗建议,的病人由于害怕拒绝注射。此后强的松和类风湿数量和大小结节逐渐减少。

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