...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Biology of Reproduction: Offical Journal of the Society for the Study of Reproduction >Morphogenesis of the female reproductive tract along antero-posterior and dorso-ventral axes is dependent on Amhr2+mesenchyme in mice(dagger)
【24h】

Morphogenesis of the female reproductive tract along antero-posterior and dorso-ventral axes is dependent on Amhr2+mesenchyme in mice(dagger)

机译：雌性生殖道沿前后轴和背腹轴的形态发生依赖于小鼠的Amhr2+间充质（匕首）

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Amhr2+ mesenchyme regulates morphogenesis of the female reproductive tract along antero-posterior and dorso-ventral axes. Morphogenesis of the female reproductive tract is regulated by the mesenchyme. However, the identity of the mesenchymal lineage that directs the morphogenesis of the female reproductive tract has not been determined. Using in vivo genetic cell ablation, we identified Amhr2+ mesenchyme as an essential mesenchymal population in patterning the female reproductive tract. After partial ablation of Amhr2+ mesenchymal cells, the oviduct failed to develop its characteristic coiling due to decreased epithelial proliferation and tubule elongation during development. The uterus displayed a reduction in size and showed decreased cellular proliferation in both epithelial and mesenchymal compartments. More importantly, in the uterus, partial ablation of Amhr2+ mesenchyme caused abnormal lumen shape and altered the direction of its long axis from the dorsal-ventral axis to the left-right axis (i.e., perpendicular to the dorsal-ventral axis). Despite these morphological defects, epithelia underwent normal differentiation into secretory and ciliated cells in the oviduct and glandular epithelial cells in the uterus. These results demonstrated that Amhr2+ mesenchyme can direct female reproductive tract morphogenesis by regulating epithelial proliferation and lumen shape without affecting the differentiation of epithelial cell types.
机译：Amhr2 +间质调节的形态发生沿着antero-posterior女性生殖系统和背腹轴。女性生殖系统的监管间质。间叶细胞谱系,指导女性生殖系统的形态发生还未确定。细胞消融,我们认为Amhr2 +间质一个重要的间充质人口模式女性生殖系统。消融Amhr2 +间充质细胞,输卵管未能发展特点卷减少上皮增殖和小管在开发过程中伸长。减少尺寸和显示显示减少细胞增殖上皮和间充质隔间。重要的是,在部分切除子宫Amhr2 +间质内腔形状和异常造成的改变的长轴的方向dorsal-ventral轴,左右轴(即垂直于dorsal-ventral轴)。尽管有这些缺陷形态,上皮细胞接受正常分化为分泌输卵管的纤毛细胞和腺体在子宫上皮细胞。证明Amhr2 +间质可以直接女性生殖系统形态发生调节上皮增生和管腔形状没有分化的影响上皮细胞类型。

著录项

相似文献

  • 外文文献
  • 中文文献
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号