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首页> 外文期刊>Biology of Reproduction: Offical Journal of the Society for the Study of Reproduction >Peptidylarginine deiminase enzymes and citrullinated proteins in female reproductive physiology and associated diseases(dagger)
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Peptidylarginine deiminase enzymes and citrullinated proteins in female reproductive physiology and associated diseases(dagger)

机译：肽基精氨酸脱亚胺酶和瓜氨酸蛋白在女性生殖生理及相关疾病中的应用（匕首）

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摘要

Citrullination, the post-translational modification of arginine residues, is catalyzed by the four catalytically active peptidylarginine deiminase (PAD or PADI) isozymes and alters charge to affect target protein structure and function. PADs were initially characterized in rodent uteri and, since then, have been described in other female tissues including ovaries, breast, and the lactotrope and gonadotrope cells of the anterior pituitary gland. In these tissues and cells, estrogen robustly stimulates PAD expression resulting in changes in levels over the course of the female reproductive cycle. The best-characterized targets for PADs are arginine residues in histone tails, which, when citrullinated, alter chromatin structure and gene expression. Methodological advances have allowed for the identification of tissue-specific citrullinomes, which reveal that PADs citrullinate a wide range of enzymes and structural proteins to alter cell function. In contrast to their important physiological roles, PADs and citrullinated proteins are also involved in several female-specific diseases including autoimmune disorders and reproductive cancers. Herein, we review current knowledge regarding PAD expression and function and highlight the role of protein citrullination in both normal female reproductive tissues and associated diseases. Peptidylarginine deiminase enzymes are expressed in female reproductive tissues and post-translationally convert arginine residues in target proteins to citrulline.
机译：Citrullination,翻译后精氨酸残基的改性催化由四个peptidylarginine催化地活跃deiminase(垫或PADI)同功酶和改变影响靶蛋白结构和收费函数。啮齿动物子宫,自那时以来,已被描述在其他女性组织包括卵巢,乳房,和lactotrope gonadotrope细胞前的脑下垂体。和细胞,雌激素强劲刺激垫表达水平的变化女性生殖周期的进程。最合适的目标垫是精氨酸残留在组蛋白尾巴,当citrullinated、改变染色质结构和基因表达式。对组织的识别citrullinomes,这表明,垫citrullinate多种酶和结构蛋白改变细胞的功能。其重要的生理角色相比,垫和citrullinated蛋白质也参与其中包括在几个一级的疾病自身免疫性疾病和生殖癌症。在此,我们回顾当前的知识关于垫表达和功能和强调的作用蛋白质citrullination在两个正常的女性生殖组织和相关疾病。Peptidylarginine deiminase酶表达在女性生殖组织和你将精氨酸残基目标蛋白质瓜氨酸。

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