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首页> 外文期刊>Chinese journal of academic radiology. >Neuroimaging advances in chemotherapy-related cognitive impairment: from clinical to preclinical research
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Neuroimaging advances in chemotherapy-related cognitive impairment: from clinical to preclinical research

机译：化疗相关认知障碍的神经影像学进展：从临床到临床前研究

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Abstract Chemotherapy-related cognitive impairment (CRCI) is a common complication in patients with non-central nervous system malignancies after chemotherapy and significantly impacts the quality of life of survivors. It is essential to understand the neuroimaging mechanism of CRCI to provide a theoretical basis for clinical rehabilitation strategies as the number of survivors at risk for acute and long-term CRCI is increasing dramatically. In this review, we summarize the main neuroimaging features and findings of clinical patients and preclinical animals with CRCI from structural and functional measurements to molecular imaging, from regional to network-based large-scale analysis, from metabolite concentration to blood perfusion status, and from single-modal group-level statistics to multimodal and individual prediction, with the aim to elaborate on multiple-image signatures of patients and animals with cognitive impairment induced by chemotherapy. In addition, the emerging trend of neuroimaging applications in the comprehensive multimodal and individual prediction in patients with CRCI is addressed. Overall, the review explored the heterogeneity of neuropathological mechanisms of CRCI with neuroimaging technology and verified the findings from clinical to preclinical research. The neuropathological mechanism of CRCI involves abnormal alterations not only in morphology, structure, and functions but also in neuro-electrophysiology, biochemical metabolites, and blood perfusion in related brain regions associated with cognition. We conclude that neuroimaging techniques, particularly multimodal neuroimaging techniques, have great potential in identifying underlying neurobiological alterations associated with CRCI. Longitudinal studies with larger sample sizes combined with individual predictions and molecular imaging technology are still warranted to prove their practical utility for more medications than just chemotherapy.
机译：文摘Chemotherapy-related认知障碍(CRCI)是一种常见的并发症患者偏心的神经系统恶性肿瘤化疗和显著影响幸存者的生活质量。理解CRCI的神经成像机制为临床提供了理论依据康复策略的数量幸存者急性和长期CRCI的风险大幅增加。总结主要的神经影像学特点和临床病人和临床结果动物CRCI从结构和功能测量分子成像,从区域基于网络的大规模分析代谢物浓度血液灌注状态,从single-modal组级别多通道和个人数据预测,旨在阐述多重象签名的病人和动物引起的认知障碍化疗。在综合神经成像应用多通道和个人预测的病人与CRCI解决。探索神经病理学的异质性CRCI机制与神经成像技术和临床验证的结果临床前研究。CRCI机制涉及异常改变不仅在形态、结构和功能而且在neuro-electrophysiology、生化在大脑相关代谢物,血液灌注地区与认知有关。神经影像技术,特别是多通道神经影像技术,有很大的潜力,识别潜在的神经生物学的改变与CRCI有关。纵向研究与更大的样本量结合个人的预测和分子成像技术仍然是必要的为了证明他们的实用性比化疗药物。

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