Main Fabrication Methods of Micellar Nanoparticles for Nanoscale Tumor Therapy through the Self-assembly of Amphiphilic Copolymers

Fan Jia; Shishuai Su; Ruirui ZhangYan Wu

首页> 外文期刊>Current Chinese Science. >Main Fabrication Methods of Micellar Nanoparticles for Nanoscale Tumor Therapy through the Self-assembly of Amphiphilic Copolymers

【24h】

Main Fabrication Methods of Micellar Nanoparticles for Nanoscale Tumor Therapy through the Self-assembly of Amphiphilic Copolymers

机译：两亲性共聚物自组装纳米肿瘤治疗胶束纳米颗粒的主要制备方法

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Micellar nanoparticles synthesized through the self-assembly of amphiphilic copolymers have been widely used to encapsulate various cancer therapeutic agents for preclinical and clinical applications. These drug delivery systems are easy to fabricate and have good biocompatibility in general. In this article, we provide an overview of the advantages and disadvantages of micellar nanoparticles for the fabrication of therapeutic agent-loaded nanoparticles from amphiphilic copolymers, the examples of common polymer materials, and methods used to prepare micellar nanoparticles, including emulsion solvent evaporation method, double emulsion method, nanoprecipitation method, etc. By choosing an appropriate technique, different therapeutic agents with different properties can be incorporated into nanoparticles individually or in combination. We analyzed the parameters of various preparation methods, with particular emphasis on improvements in improved techniques for simultaneous co-loading of hydrophilic/hydrophobic drugs and therapeutic nucleic acids in a single nanoparticle. It will allow researchers to choose the appropriate method to design therapeutic agent-loaded micellar nanoparticles from amphiphilic copolymers.

机译：胶束纳米粒子合成的两亲性共聚物的自组装广泛用于封装各种癌症为临床前和临床治疗药物应用程序。容易制造,具有良好的生物相容性一般来说。的优点和缺点的概述胶束纳米颗粒的制造治疗agent-loaded纳米粒子从两亲性共聚物,常见的例子高分子材料和方法使用的准备胶束纳米粒子,包括乳液溶剂蒸发法、双乳液法、nanoprecipitation法等。选择一个适当的技术,不同与不同的属性可以治疗药物分别被纳入纳米颗粒或结合在一起。不同的制备方法,特别强调改进技术的改进同时同行并装的亲水/疏水性药物和治疗核酸在单个纳米粒子。允许研究人员选择合适的设计方法治疗agent-loaded胶束纳米粒子从两亲性共聚物。

著录项

来源
《Current Chinese Science.》 |2022年第4期|263-274|共12页
作者
Fan Jia; Shishuai Su; Ruirui ZhangYan Wu;
展开▼
作者单位

Chinese Academy of Sciences Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety;

展开▼
收录信息
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词

相似文献

外文文献
中文文献

1. SYNTHESIS OF pH-RESPONSIVE AMPHIPHILIC DIBLOCK COPOLYMERS CONTAINING POLYISOBUTYLENE via OXYANION-INITIATED POLYMERIZATION AND THEIR MULTIPLE SELF-ASSEMBLY MORPHOLOGIES [J] . Huai-chao Wang, Ming-zu Zhang, Pei-hong Ni, 高分子科学：英文版 . 2013,第002期
2. Synthesis and self-assembly of amphiphilic ABA type tribiock copolymer with well-defined glycopolymer segments [J] . WANG JianYu, QIAN YanLing, ZHANG Fan, 中国科学通报：英文版 . 2008,第9期
3. Directed self-assembly of block copolymers for sub-10 nm fabrication [J] . Yu Chen, Shisheng Xiong 极端制造（英文） . 2020,第003期
4. Intelligent self-assembly prodrug micelles loading doxorubicin in response to tumor microenvironment for targeted tumors therapy [J] . Dong Wan, Sunfan Li, Jianxin Zhang, 中国化学工程学报（英文版） . 2021,第11期
5. Self-Assembly of Amphiphilic Block Copolymer-Tethered Nanoparticles: a New Approach to Nanoscale Design of Functional Materials [J] . Liu Yi, Liu Yijing, Yin Jun-JieNie Zhihong Macromolecular rapid communications: Publishing the newsletters of the European Polymer Federation . 2015,第8期

机译：Self-Assembly of Amphiphilic Block Copolymer-Tethered Nanoparticles: a New Approach to Nanoscale Design of Functional Materials
6. Self-assembled micellar nanoparticles of a novel amphiphilic cholesteryl-poly(L-lactic acid)-b-poly(poly(ethylene glycol)methacrylate) block-brush copolymer [J] . Bagheri Massoumeh, Bigdeli Elham, Pourmoazzen Zhaleh iranian polymer journal . 2013,第4期

机译：Self-assembled micellar nanoparticles of a novel amphiphilic cholesteryl-poly(L-lactic acid)-b-poly(poly(ethylene glycol)methacrylate) block-brush copolymer
7. Fabrication of fullerene-containing hybrid vesicles via supramolecular self-assembly of a well-defined amphiphilic block copolymer incorporated with a Single C-60 moiety at the diblock junction point [J] . Wang XF, Zhang YF, Zhu ZYLiu SY Macromolecular rapid communications: Publishing the newsletters of the European Polymer Federation . 2008,第4期

机译：Fabrication of fullerene-containing hybrid vesicles via supramolecular self-assembly of a well-defined amphiphilic block copolymer incorporated with a Single C-60 moiety at the diblock junction point
8. Hyaluronic acid-polylactic acid copolymers as carriers for tumor therapy [O] . 陳俞如, Chen, Yu-Ru 2014

机译：Hyaluronic acid-polylactic acid copolymers as carriers for tumor therapy

Main Fabrication Methods of Micellar Nanoparticles for Nanoscale Tumor Therapy through the Self-assembly of Amphiphilic Copolymers

摘要

著录项

相似文献

相关主题

期刊订阅