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首页> 外文期刊>Journal of the American Animal Hospital Association >Successful Use of Mycophenolate Mofetil as Adjunct to Prednisolone for Treatment of Acute Kidney Injury Secondary to Human Serum Albumin Administration in a Dog
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Successful Use of Mycophenolate Mofetil as Adjunct to Prednisolone for Treatment of Acute Kidney Injury Secondary to Human Serum Albumin Administration in a Dog

机译：成功使用吗替麦考酚酯作为泼尼松龙的辅助治疗继发于狗人血清白蛋白给药的急性肾损伤

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摘要

The use of human serum albumin (HSA) is described in dogs receiving critical care. However, despite the high degree of homology, anaphylactic and delayed hypersensitivity reactions are reported. Delayed type III hypersensitivity reactions can lead to glomerulonephritis and acute kidney injury (AKI). Undiluted 20% HSA was administered to a 4.8 yr old intact male Labrador Retriever with severe hypoalbuminemia, following surgical management of septic peritonitis of gastroin-testinal origin. Nineteen days after HSA administration, the dog developed peracute high magnitude renal proteinuria and AKI. Rapid immunosuppression, using a combination of prednisolone and mycophenolate mofetil, resulted in full resolu-tion of AKI, hypoalbuminemia, and proteinuria. Addition of mycophenolate mofetil may have resulted in the first docu-mented case of full renal recovery from hypersensitivity-induced AKI caused by HSA administration.
机译：人血清白蛋白(HSA)的使用在狗狗接受急救护理。高度的同源性,过敏和报告迟发过敏性反应。延迟III型超敏反应导致肾小球肾炎和急性肾损伤(AKI)。4.8岁完整的男性的拉布拉多寻回犬严重的低白蛋白血症,手术后管理的感染性腹膜炎gastroin-testinal来源。政府,狗急性的高发展级肾蛋白尿和阿基。免疫抑制,使用的组合强的松和霉酚酸酯在全面resolu-tion阿基,低白蛋白血症,蛋白尿。可能导致第一docu-mented情况的肾复苏hypersensitivity-induced阿基HSA所致管理。

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