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首页> 外文期刊>Journal of the American Animal Hospital Association >Combined Hypofractionated Radiotherapy and Chemotherapy Versus Hypofractionated Radiotherapy Alone for Cats with Localized Sinonasal Lymphoma
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Combined Hypofractionated Radiotherapy and Chemotherapy Versus Hypofractionated Radiotherapy Alone for Cats with Localized Sinonasal Lymphoma

机译：大分割放化疗联合与单独大分割放疗治疗局限性鼻窦淋巴瘤猫的比较

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Despite considering hypofractionated radiotherapy (HRT) a useful treatment option for feline localized sinonasal lym-phoma (stage I), the benefits of additional chemotherapy remain controversial. This retrospective cohort study evaluated the efficacy of the early initiation of chemotherapy in combination with HRT (HRTC) to prolong the progression-free sur-vival (PFS) and overall survival (OS) in cats with localized sinonasal lymphoma compared with HRT alone. While 24 eligi-ble cats received HRT alone (HRT group), 18 received HRTC (HRTC group). The total median administered dose was 35 Gy, with one fraction per week, for a median of five fractions. In the HRTC group, the chemotherapy protocol was cyclo-phosphamide, doxorubicin, vincristine, and prednisolone (CHOP)-based and cyclophosphamide, vincristine, and prednis-olone (COP)-based in 14 (78%) and 4 cats (22%), respectively. Cats in the HRTC group had significantly longer PFS (677 versus 104 days; P = .04) and OS (983 versus 263 days; P = .04) than those in the HRT group. Considering the poor out-come in the HRT group despite the cats having received rescue chemotherapy for progressive disease, the early initia-tion of additional chemotherapy along with HRT may be recommended for feline localized sinonasal lymphoma. (J Am Anim Hosp Assoc 2022; 58:254-261. DOI 10.5326/JAAHA-MS-7267)
机译：尽管考虑hypofractionated放射治疗猫(HRT)一个有用的治疗选择鼻腔鼻窦lym-phoma细菌本地化(I期)额外的好处化疗仍然存在有争议的。评估的早期启动的功效化疗结合激素替代疗法(HRTC)延长无进展生存期(PFS)总生存期(OS)与本地化的猫独自sinonasal淋巴瘤与荷尔蒙替代疗法。24 eligi-ble猫仅接受激素替代治疗(HRT组),18收到HRTC (HRTC组)。服用剂量是35 Gy,用一个分数每周,平均五个分数。化疗HRTC集团协议cyclo-phosphamide、阿霉素、长春新碱和强的松(切)的和环磷酰胺,长春新碱,prednis-olone (COP)的14个猫(78%)和4(22%),分别为。HRTC组显著延长PFS (677与104天;天;考虑穷人荷尔蒙替代疗法组的成果尽管猫收到救援化疗进行性疾病,早期initia-tion额外的化疗荷尔蒙替代疗法可能会推荐给猫本地化sinonasal淋巴瘤。58:254-261。

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