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首页> 外文期刊>Journal of cellular physiology. >Inactivation of Sufu in cementoblasts accelerates external tooth root resorption
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Inactivation of Sufu in cementoblasts accelerates external tooth root resorption

机译：牙骨质母细胞中 Sufu 的失活加速了牙根外吸收

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Abstract Cementum has been empirically regarded as an antiresorptive barrier against tooth roots. However, little is known about the factors of homeostasis and resistant mechanisms of tooth roots against resorption. Here, we investigated cementum factors and their interaction against resorption using transgenic mice exhibiting external cervical root resorption (ECRR). Ectopically thickened cervical cementum caused by functional inactivation of ectonucleotide pyrophosphotase/phosphodiesterase 1 (Enpp1) was susceptible to ECRR with aging. In addition, the inactivation of the suppressor of fused (Sufu), a Hedgehog signaling inhibitor, in cementoblasts led to ECRR. Interestingly, concurrent inactivation of Sufu and Enpp1 in cementoblasts remarkably exacerbated ECRR with higher Rankl expression. Cellular and molecular analyses using cementoblasts and bone marrow‐derived macrophages indicated that Dickkopf‐related protein 1 (Dkk1) induced by the inactivation of Sufu in cementoblasts has roles in the acceleration of ECRR triggered by Enpp1 inactivation. Using compound mutant mice for concurrent Wntless and Enpp1 inactivation, this synergistic cooperation of Dkk1 and Npp1 for resorption found in double mutant Sufu and Enpp1 mice was confirmed by the reproduction of amplified ECRR. On the basis of these findings, we conclude that proper Npp1 function and sustained Wnt activity in the cervical cementum are essential for the homeostasis of tooth roots against resorption in a physiological state.
机译：抽象的水门汀经验视为开出抗再吸收屏障对牙齿的一个根源。然而,人们很少知道的因素体内平衡和耐药机制的牙齿根吸收。牙骨质的因素及其相互作用使用转基因小鼠表现出吸收外部颈根吸收(ECRR)。Ectopically颈牙骨质增厚所致功能失活ectonucleotidepyrophosphotase /磷酸二酯酶1 (Enpp1)容易ECRR老化。抑制基因的失活融合(Sufu)刺猬信号传导抑制剂,在成牙骨质细胞导致ECRR。在成牙骨质细胞失活Sufu和Enpp1显著加剧ECRR Rankl与高表达式。成牙骨质细胞和骨髓中巨噬细胞表明Dickkopf应承担的相关蛋白1 (Dkk1)引起Sufu的失活成牙骨质细胞的加速作用ECRR Enpp1引发的失活。为并发Wntless和复合突变小鼠Enpp1失活,协同合作Dkk1和Npp1吸收双中找到突变Sufu和Enpp1老鼠了放大ECRR繁殖。这些研究结果,我们认为适当的Npp1功能和持续的Wnt活动颈部牙骨质的至关重要内稳态的牙齿根与吸收一种生理状态。

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