Noncoding RNAs in diagnosis and prognosis of graft‐versus‐host disease (GVHD)

Mahdi K. Vajari; Susan Moradinasab; Amir‐Mohammad YousefiDavood Bashash

摘要

Abstract Allogeneic hematopoietic stem cell transplantation (allo‐HSCT) is a functional therapy for a plethora of hematologic malignancies and immune disorders. Graft‐versus‐host disease (GVHD), on the other hand, is one of the major complications ahead of a successful HSCT, contributing to transplant‐associated morbidity and mortality. Notably, little is known about the underlying mechanism of this event; therefore, exploring precise biomarkers and uncovering the molecular pathogenesis of GVHD is valuable for early diagnosis and treatment optimization. Thanks to the advances in sequencing techniques, the noncoding sequences of the human genome—formerly considered "junk"—are now identified as functional molecules. Noncoding RNAs (ncRNA) control cellular responses by regulating gene expression, and previous studies have shown that these tiny molecules, especially microRNAs (miRNAs), can affect allogeneic T cell responses in both animal models and clinical experiments. The present study gives an overview of the functions of various miRNAs in regulating T cell responses in GVHD. We also provide an outlook on miRNAs and long noncoding RNAs (lncRNAs) potential role in GVHD with the hope of providing a future research direction for expanding their application as the sensitive and noninvasive diagnostic or prognostic biomarkers and also the promising therapeutic targets for improving outcomes after allogeneic HSCT.

机译：抽象的同种异体造血干细胞移植(喂必经HSCT)是一个功能治疗大量的血液恶性肿瘤和免疫紊乱。移植量与宿主病(GVHD)应承担的一方面,是前面的主要并发症之一一个成功的HSCT,导致移植相关的发病率和死亡率。值得注意的是,底层是知之甚少这个事件的机制;精确的生物标志物和发现的分子发病的早期移植物抗宿主病是有价值的诊断和治疗的优化。测序技术的进步,人类genome-formerly的非编码序列被认为是“垃圾”——现在确定为功能分子。通过调节基因控制细胞反应表情,和以前的研究已经表明这些小分子,尤其是小分子核糖核酸(microrna),会影响同种异体T细胞反应在这两种动物模型和临床实验。目前的研究概述各种microrna在调节T细胞的功能在GVHD反应。microrna和长非编码rna (lncRNAs)在移植物抗宿主病希望提供潜在的作用扩大他们的未来的研究方向应用敏感和非侵入性诊断或预后的生物标志物和有前途的治疗改善的目标同种异体HSCT后的结果。

Noncoding RNAs in diagnosis and prognosis of graft‐versus‐host disease (GVHD)

摘要

著录项

相关主题

期刊订阅