N6‐methyladenosine (m6A) modification in gynecological malignancies

Chunmei Zhang; Ning Liu

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N6‐methyladenosine (m6A) modification in gynecological malignancies

机译：妇科恶性肿瘤中的N6-甲基腺苷（m6A）修饰

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Abstract N6‐methyladenosine (m6A) modification is one of the most abundant modifications in eukaryotic mRNA, regulated by m6A methyltransferase and demethylase. m6A modified RNA is specifically recognized and bound by m6A recognition proteins, which mediate splicing, maturation, exonucleation, degradation, and translation. In gynecologic malignancies, m6A RNA modification‐related molecules are expressed aberrantly, significantly altering the posttranscriptional methylation level of the target genes and their stability. The m6A modification also regulates related metabolic pathways, thereby controlling tumor development. This review analyzes the composition and mode of action of m6A modification‐related proteins and their biological functions in the malignant progression of gynecologic malignancies, which provide new ideas for the early clinical diagnosis and targeted therapy of gynecologic malignancies.

机译：抽象N6 methyladenosine应承担(m6A)修改最丰富的修改真核mRNA,由m6A规定甲基转移酶和demethylase。RNA是专门识别和受m6A识别蛋白质调解拼接,成熟,exonucleation、退化和翻译。修改相关分子表达,异常的显著改变转录后的甲基化水平目标基因及其稳定性。修改也调节相关的代谢通路,从而控制肿瘤的发展。本文分析的成分和模式m6A修改量相关的蛋白质和行动他们在恶性生物功能妇科恶性肿瘤的进展为临床早期提供新思路诊断和靶向治疗妇科的恶性肿瘤。

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《Journal of cellular physiology.》 |2022年第9期|3465-3479|共15页
作者
Chunmei Zhang; Ning Liu;
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作者单位

Department of Obstetrics and Gynecology,Shengjing Hospital of China Medical University;

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正文语种英语
中图分类细胞生物学;
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N6‐methyladenosine (m6A) modification in gynecological malignancies

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