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首页> 外文期刊>Venoms and Toxins >Current Ion Channel-targeted Drugs and Potential of Venom-derived Peptides as a Therapeutic New Modality
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Current Ion Channel-targeted Drugs and Potential of Venom-derived Peptides as a Therapeutic New Modality

机译：目前的离子通道靶向药物和毒液衍生肽作为治疗新模式的潜力

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摘要

Ion channel function is essential for maintaining life and is involved in various physiological activities. However, various factors such as heredity, aging, wounding, and diseases can cause abnormalities in ion channel function and expression. Such channel abnormalities can interfere with the healthy activities of the organism and threaten the maintenance of life. There are many types of ion channels, and their roles are diverse. In recent years, it is becoming clear that ion channels are intrinsically involved in various diseases beyond what has been previously thought. Therefore, it is highly desirable to develop more drugs by increasing various channels for drug discovery and various diseases. In this review, we will introduce the ion channels currently targeted for drug discovery and the mechanisms by which these channels are involved in diseases, focusing on information compiled on the internet. Currently, the target ion channels for drug development and treating diseases are becoming more diverse. The drugs under development are not only small molecules, which account for most of the ion channel drugs developed to date, but also different types of drugs, such as antibodies, peptides, and oligonucleotides. Due to low specificity, many existing ion channel drugs have side effect problems. Diversification of drugs may facilitate the resolution of these problems, and venom-derived peptide drugs are a promising class of future agents that can contribute to this end. In the last part of this review, the status of drug development of venom-derived peptides will also be discussed.
机译：离子通道功能的维持至关重要生活和参与各种生理活动。遗传、老化、伤害和疾病可引起在离子通道功能和异常表达式。干扰的健康活动生物和威胁生命的维护。有许多类型的离子通道,他们角色是多样化的。变得明显,离子通道本质上参与各种疾病是以前的想法。是高度需要开发更多的药物提高药物发现的各种渠道和各种疾病。介绍了当前针对离子通道药物发现和这些机制渠道参与疾病,关注信息在互联网上编译。离子通道药物开发和目标治疗疾病也正变得更加多样化。药物正在开发不仅是小分子,占大部分的离子通道的药物开发迄今为止,但也不同类型的药物,如抗体、肽、寡核苷酸。特异性,许多现有的离子通道药物副作用的问题。可能有助于解决这些问题,和venom-derived肽药物是一种很有前途的类未来的代理,可以提供这一目的。venom-derived药物开发的状态肽也将被讨论。

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