Venomous Peptides as Cardiac Ion Channel's Modulators

Sree Vandana Yerramsetty; Hitesh Chopra; Viajaya Nirmala Pangi

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Venomous Peptides as Cardiac Ion Channel's Modulators

机译：毒肽作为心脏离子通道的调节剂

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Venoms from the deadliest animals, including spiders, scorpians, bees, and centipedes, are composed of a complex mixture of various peptides developed to catch prey and defend other animals. Venoms are composed of several bioactive molecules such as proteins and peptides that modify physiological conditions in other organisms. These bioactive peptides penetrate tissues and blood vessels to encounter numerous receptors and modulate ion channel their activities. Venoms are used to treat various medical issues, including cardiovascular diseases. Venom peptides regulate several ion channel behaviors, such as voltage-gated sodium (Nav), calcium (Cav) and potassium (Kv) channels, and are set as a therapeutic approach. In this perspective, we emphasize the effect of isolated lethal venomous peptides on cardiac ionic channels and their mechanisms of action for the cure. We also summarize the highlights and molecular details of their toxin-receptor interactions and prospects to develop peptide therapeutics for respective cardiac electrophysiological diseases.

机译：致命的毒液动物,包括蜘蛛,天蝎,蜜蜂,蜈蚣组成的一个复杂的各种肽的混合物捕获猎物和保护其他动物。毒液是由多种生物活性分子如蛋白质和多肽修改其他的生理条件生物。组织和血管遇到无数受体和调节离子通道活动。医疗问题,包括心血管疾病。通道的行为,比如电压门控钠(Nav),钙(Cav)和钾(Kv)频道,并设置为治疗方法。的角度来看,我们强调孤立的效果致命的毒肽在心脏离子渠道和他们的行动机制治疗。分子毒素受体的细节相互作用和前景发展肽治疗为各自的心脏电生理疾病。

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《Venoms and Toxins》 |2022年第2期|12-20|共9页
作者
Sree Vandana Yerramsetty; Hitesh Chopra; Viajaya Nirmala Pangi;
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作者单位

Department of Chemical and Biotechnology, SASTRA Deemed University, Thanjavur, Tamil Nadu-613402, India;

Chitkara College of Pharmacy, Chitkara University, Punjab-140401, India;

School of Life and Health Sciences, Adi-kaviNannaya University, Rajahamahendravaram, Andhra Pradesh, India;

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正文语种英语
中图分类药学;
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4. The transient receptor potential melastatin 4 channel inhibitor 9‐phenanthrol modulates cardiac sodium channel [J] . Hou Jian‐wen, Fei Yu‐dong, Li WeiChen Yi‐heWang QianXiao YingWang Yue‐pengLi Yi‐gang British Journal of Pharmacology . 2018,第23期

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5. Potassium channel activators differentially modulate the effect of sodium channel blockade on cardiac conduction [J] . VeeraraghavanR., LarsenA.P., TorresN.S.GrunnetM.PoelzingS. Acta physiologica . 2013,第2期

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7. Channel-Max, Channel-Drop and Stochastic Max-pooling [C] . Yuchi Huang, Xiuyu Sun, Ming Lu, IEEE Conference on Computer Vision and Pattern Recognition Workshops . 2015

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8. The polymorphic residue 129 of the prion protein determines the efficiency of prion propagation. [D] . Mallik, Suparna. 2009

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9. Optimization of Conditions for Production of Channel Catfish Ovary Cells and Channel Catfish Virus DNA [O] . Tracey E. Colyer, John A. Boyle 1985

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10. Investigation of the effect of the precursor ion heterogeneity on the fragmentation of the model peptides under electron capture dissociation. [O] . 2011

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11. Evaluation of Electro-Medical Equipment. Evaluation of Defibrillators. First Report. American Optical Pulsar 4, Cambridge 01043, Cambridge 73618, Cardiac Recorders 'Life Aid' 272, Cardiac Recorders 'Pantridge' 280, Mennen Greatbatch 936/S, Philips BD400 [R] . 1980

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Venomous Peptides as Cardiac Ion Channel's Modulators

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