Genome response of hippocampal cells to stress in male rats with different excitability of the nervous system

Veronika Shcherbinina; Alexander Vaido; Diana KhlebaevaNatalia DyuzhikovaEugene Daev

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Genome response of hippocampal cells to stress in male rats with different excitability of the nervous system

机译：Genome response of hippocampal cells to stress in male rats with different excitability of the nervous system

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Changes of genome stability in hippocampal cells of male rats with hereditary high and low thresholds of nervus tibialis response to electric stimuli (HT and LT strains, respectively) were studied in unstressed and stressed animals. HT and LT originated from Wistar strain, males of which were also used as a control. The comet assay was used after prolonged emotional painful stressor action. There were no interstrain differences in the spontaneous percentage of DNA in comet tails (tDNA). However, the prolonged emotional pain stressor induced genome instability differently in animals of different strains. The highest level of DNA damage in hippocampal cells was shown in highly sensitive animals of LT strain. Males of Wistar strain had intermediate levels of tDNA, while HT animals had the lowest stress reactivity.

机译：在海马细胞基因组稳定性的变化雄性老鼠的遗传性高和低胫神经反应的阈值电刺激(HT和LT菌株,)在重读而进行了研究强调动物。纯种菌株,其中男性也被用作控制。情感痛苦的压力作用。不同品系间的差异在自发的比例的DNA彗星尾巴(tDNA)。长期情绪痛苦压力诱导动物的基因组不稳定性不同不同的菌株。损伤海马细胞是高度所示LT应变敏感动物。应变tDNA中级水平,而HT动物应激反应性最低。

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《Biological communications》 |2022年第1期|12-18|共7页
作者
Veronika Shcherbinina; Alexander Vaido; Diana KhlebaevaNatalia DyuzhikovaEugene Daev;
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Department of Genetics and Biotechnology, Faculty of Biology, Saint Petersburg State University, Universitetskaya nab., 7-9, Saint Petersburg, 199034, Russian Federation;

Laboratory of Higher Nervous Activity Genetics, Pavlov Institute of Physiology, Russian Academy of Sciences, nab. Makarova, 6, Saint Petersburg, 199034, Russian Federation;

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中图分类普通生物学;
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Genome response of hippocampal cells to stress in male rats with different excitability of the nervous system

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