Biochanin-A: A Bioactive Natural Product with Versatile Therapeutic Perspectives

Vadivelan Ramachandran; Inba V; Kiran hrRuchi TiwariGaurav Tiwari

摘要

Background: Biochanin-A (5,7 dihydroxy 4 methoxy isoflavone) is a phytochemical phytoestrogen that is highly effective against various diseases. Biochanin-A is a nutritional and dietary isoflavonoid naturally present in red clover, chickpea, soybeans and other herbs. Biochanin- A possesses numerous biological activities. Objective: The study focused on collective data of therapeutic activities of Biochanin-A. Methods: According to the literature, biochanin-A revealed a range of activities starting from chemoprevention, by hindering cell growth, activation of tumor cell death, hampering metastasis, angiogenic action, cell cycle regulation, neuroprotection, by controlling microglial activation, balancing antioxidants, elevating the neurochemicals, suppressing BACE-1, NADPH oxidase hindrance to inflammation, by mitigating the MAPK and NF- κB, discharge of inflammatory markers, upregulating the PPAR-γ, improving the function of heme oxygenase-1, erythroid 2 nuclear factors, detoxifying the oxygen radicals and stimulating the superoxide dismutase action, and controlling its production of transcription factors. Against pathogens, biochanin-A acts by dephosphorylating tyrosine kinase proteins, obstructing gram-negative bacteria, suppressing the development of cytokines from viruses, and improving the action of a neuraminidase cleavage of caspase-3, and acts as an efflux pump inhibitor. In metabolic disorders, biochanin-A acts by encouraging transcriptional initiation and inhibition, activating estrogen receptors, and increasing the activity of differentiation, autophagy, inflammation, and blood glucose metabolism. Conclusion: Therefore, biochanin-A could be used as a therapeutic drug for various pathological conditions and treatments in human beings.

机译：背景:Biochanin-A(5、7二羟基4甲氧基异黄酮)是一种植物化学的植物雌激素对各种疾病非常有效。Biochanin-A营养和饮食isoflavonoid自然存在于红三叶草,鹰嘴豆、大豆和其他草药。具有许多生物活性。目的:研究集中在集体数据治疗Biochanin-A活动。方法:根据文献,biochanin-A显示从一系列的活动化学预防,通过阻碍细胞生长,激活肿瘤细胞死亡,阻碍转移、血管生成作用、细胞周期规定,神经保护,通过控制小胶质激活,平衡抗氧化剂,提高化学物质,抑制BACE-1,炎症,NADPH氧化酶障碍减轻MAPK和NF -κB,放电炎症标记物,移植PPAR -γ,提高血红素oxygenase-1的功能,红细胞2核因素,排毒氧自由基和刺激过氧化物歧化酶行动,并控制其生产的转录因子。脱去磷酸酪氨酸biochanin-A行为蛋白质激酶,阻碍革兰氏阴性细菌,抑制的发展从病毒的细胞因子,改善行动神经氨酸酶的乳沟caspase-3,充当外排泵抑制剂。障碍,通过鼓励biochanin-A行为转录起始和抑制,激活雌激素受体,和增加活动的区别,自噬,炎症和血液葡萄糖代谢。结论:因此,biochanin-A可以被使用作为各种病理的治疗药物条件和治疗人类。

Biochanin-A: A Bioactive Natural Product with Versatile Therapeutic Perspectives

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