Therapeutic Potential of Diacerein in Management of Pain

Vishal Patel; Amit Joharapurkar; Mukul Jain

摘要

Diacerein (DCN), an analogue of rhein (a glycosidal compound of natural origin), is currently used in the treatment of osteoarthritis and is given a fast-track designation for development to treat epidermolysis bullosa (EB). It is a nonsteroidal anti-inflammatory drug having disease-modifying properties in osteoarthritis and anti-inflammatory effects for the treatment of EB. Diacerein has a beneficial effect on pain relief and demonstrated antioxidant and anti-apoptotic effects, which are useful in renal disease, diabetes, and other disorders. This review discusses the possible mechanism of diacerein in the management of pain. The potential role of rhein and diacerein in the treatment of neuropathic, inflammatory and nociceptive pain is also reviewed. The effect of diacerein and rhein on mediators of pain, such as transient receptor potential cation channel subfamily V (TRPV1), Substance P, glutamate, inflammatory cytokines, nitric oxide, matrix metalloproteinases, histamine, palmitoylethanolamide, nuclear factor-kappa B (NFkB), and prostaglandin, has also been discussed. The data highlights the role of diacerein in neuropathic, nociceptive and inflammatory pain. Clinical trials and mechanism of action studies are needed to ascertain the role of diacerein, rhein or their analogues in the management of pain, alone or in combination with other approved therapies.

机译：Diacerein(宽带),大黄酸(的模拟glycosidal自然起源的化合物),目前用于治疗骨关节炎给出一个快速通道的名称发展表皮松解治疗大疱(EB)。它是一种非甾体类抗炎药物在疾病修饰属性骨关节炎和抗炎作用EB的治疗。缓解疼痛,并演示了抗氧化剂和抗凋亡作用,有用在肾脏疾病,糖尿病和其他障碍。diacerein在疼痛的管理机制。大黄酸和diacerein的潜在作用治疗神经性炎症和疼痛的痛苦也回顾了。diacerein和大黄酸介质的疼痛,如瞬时受体电位阳离子通道亚科V (TRPV1)、P物质、谷氨酸,炎性细胞因子、一氧化氮、矩阵金属蛋白酶、组胺、palmitoylethanolamide,核factor-kappa B(NFkB)和前列腺素也进行了讨论。diacerein在神经性疼痛的炎症性疼痛。确定所需的行动研究diacerein,大黄酸或其类似物疼痛的管理,单独或结合在一起与其他批准的疗法。

Therapeutic Potential of Diacerein in Management of Pain

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