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Are Histamine H 3 Antagonists the Definitive Treatment for Acute Methamphetamine Intoxication?

机译：Are Histamine H 3 Antagonists the Definitive Treatment for Acute Methamphetamine Intoxication?

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摘要

Background: Methamphetamine (METH) is classified as a Schedule II stimulant drug under the United Nations Convention on Psychotropic Substances of 1971. METH and other amphetamine analogues (AMPHs) are powerful addictive drugs. Treatments are needed to treat the symptoms of METH addiction, chronic METH use, and acute METH overdose. No effective treatment for METH abuse has been established because alterations of brain functions under the excessive intake of abused drug intake are largely irreversible due in part to brain damage that occurs in the course of chronic METH use. Objective: Modulation of brain histamine neurotransmission is involved in several neuropsychiatric disorders, including substance use disorders. This review discusses the possible mechanisms underlying the therapeutic effects of histamine H 3 receptor antagonists on symptoms of methamphetamine abuse. Conclusion: Treatment of mice with centrally acting histamine H 3 receptor antagonists increases hypothalamic histamine contents and reduces high-dose METH effects while potentiating lowdose effects via histamine H 3 receptors that bind released histamine. On the basis of experimental evidence, it is hypothesized that histamine H 3 receptors may be an effective target for the treatment METH use disorder or other adverse effects of chronic METH use.
机译：背景:甲基苯丙胺(冰毒)是机密下一个时间表II兴奋剂药物国家公约精神药品1971. (两栖的)是强大的成瘾药物。需要治疗的症状冰毒吗使用成瘾,慢性冰毒,急性冰毒过量。建立了因为改变大脑函数在摄取过多的滥用药物摄入量在很大程度上是不可逆转的部分原因过程中发生的脑损伤长期使用冰毒。组胺神经传递是参与等神经精神疾病物质使用障碍。可能的机制治疗3 H组胺受体的影响拮抗剂对甲基苯丙胺滥用的症状。结论:治疗小鼠集中行动组胺受体拮抗剂H 3下丘脑组胺含量和增加减少大剂量冰毒影响而更容易通过组胺H 3受体lowdose效果结合组胺释放。实验证据,它是假设3 H组胺受体可能是有效的目标治疗冰毒障碍或使用其他副作用的长期使用冰毒。

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  • 来源
    《Current drug research reviews.》 |2022年第3期|162-170|共9页
  • 作者

    Nobue Kitanaka; F. Hall; Koh-ichi TanakaKazuo TomitaKento IgarashiNobuyoshi NishiyamaTomoaki SatoGeorge UhlJunichi Kitanaka;

  • 作者单位

    Hyogo College of Medicine,Department of Pharmacology,Hyogo 663-8501,Japan,;

    University of Toled,Department of Pharmacology and Experimental Therapeutics, College of Pharmacy;

    Hyogo University of Health Sciences,Division of Pharmacology, Department of Pharmacy, School ofKagoshima University Graduate School of Medical and Dental Sciences,Department of AppliedNew Mexico VA Healthcare System,Neurology and Research Services,Albuquerque, New Mexico 87108New Mexico VA Healthcare System,Neurology and Research Services,Albuquerque, New Mexico 87108,NewHyogo College of Medicine,Department of Pharmacology,Hyogo 663-8501,Hyogo,Japan,663,;

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  • 原文格式 PDF
  • 正文语种 英语
  • 中图分类 药学;
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