A concise method for cyclic gem-difluoroacyl scaffolds via visible-light-mediated redox-neutral cascade radical cyclization of alkenes

Zhen Liu; Yin Wei; Min Sh

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A concise method for cyclic gem-difluoroacyl scaffolds via visible-light-mediated redox-neutral cascade radical cyclization of alkenes

机译：一种通过可见光介导的烯烃氧化还原中性级联自由基环化环化环状宝石-二氟酰基支架的简明方法

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In this paper, a series of diverse alkenes were engaged in radical tandem cyclization initiated by a CF2 radical precursor via photoredox catalysis, affording various cyclic gem-difluoroacyl arenes in good to excellent yields. This photo-induced protocol features a redox-neutral process to access a variety of gem-difluoroacyl arenes with a broad substrate scope and the structural motifs are important in pharmaceutical and agrochemical products. The mechanistic paradigm has been proposed on the basis of control and Stern-Volmer analysis experiments.

机译：在这篇文章中,一系列不同的烯烃从事激进的串联环化启动由一个通过photoredox CF2激进的前兆催化、提供各种循环gem-difluoroacyl芳烃好优秀收益率。redox-neutral访问各种各样的过程gem-difluoroacyl芳烃具有广泛的底物范围和结构图案是很重要的医药和农药产品。提出了在机械的范式控制和Stern-Volmer分析的基础实验。

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《Catalysis science & technology》 |2022年第17期|5325-5331|共7页
作者
Zhen Liu; Yin Wei; Min Sh;
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作者单位

Key Laboratory for Advanced Materials and Institute of Fine Chemicals, School of Chemistry & Molecular Engineering, East China University of Science and Technology, 130 Mei Long Road, Shanghai 200237, People's Republic of China;

State Key Laboratory of Organometallic Chemistry, Center for Excellence in Molecular Synthesis, University of Chinese Academy of Sciences, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China.;

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正文语种英语
中图分类物理化学（理论化学）、化学物理学;
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外文文献

1. A novel visible light mediated radical cyclization of enol lactones: a concise method for fluorinated polycyclic lactone scaffolds [J] . Qu Chuanhua, Xu Pan, Ma WujiangCheng YixiangZhu Chengjian Chemical communications . 2015,第70期

机译：A novel visible light mediated radical cyclization of enol lactones: a concise method for fluorinated polycyclic lactone scaffolds
2. Radical Cyclization in Heterocycle Synthesis. Part 13. Sulfanyl Radical Addition—Cyclization of Oxime Ethers and Hydrazones Connected with Alkenes for Synthesis of Cyclic β‐Amino Acids. [J] . Okiko Miyata, Kanami Muroya, Tomoko KobayashiRina YamanakaSeiko KajisaJunko KoideTakeaki Naito Chem Inform . 2002,第42期

机译：Radical Cyclization in Heterocycle Synthesis. Part 13. Sulfanyl Radical Addition—Cyclization of Oxime Ethers and Hydrazones Connected with Alkenes for Synthesis of Cyclic β‐Amino Acids.
3. ChemInform Abstract: Cascade Radical Cyclizations Leading to Steroid Ring Constructions. Regio‐ and Stereochemical Studies Using Ester‐ and Fluoro‐Alkene Substituted Polyene Acyl Radical Intermediates. [J] . Haydn M. Boehm, Sandeep Handa, Gerald PattendenLee RobertsAlexander J. BlakeWan‐Sheung Li Chem Inform . 2001,第9期

机译：ChemInform Abstract: Cascade Radical Cyclizations Leading to Steroid Ring Constructions. Regio‐ and Stereochemical Studies Using Ester‐ and Fluoro‐Alkene Substituted Polyene Acyl Radical Intermediates.

A concise method for cyclic gem-difluoroacyl scaffolds via visible-light-mediated redox-neutral cascade radical cyclization of alkenes

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