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首页> 外文期刊>Catalysis Letters >First Report About the Use of Micellar Keggin Heteropolyacids as Catalysts in the Green Multicomponent Synthesis of Nifedipine Derivatives
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First Report About the Use of Micellar Keggin Heteropolyacids as Catalysts in the Green Multicomponent Synthesis of Nifedipine Derivatives

机译：关于使用胶束Keggin杂多酸作为催化剂合成硝苯地平衍生物绿色多组分的第一篇报告

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Micellar Keggin heteropolyacid catalysts were prepared using hexadecyltrimethylammonium bromide (cetyltrimethylammonium bromide-CTAB), 1-hexadecyl-pyridinium chloride, and Keggin heteropolyacids H3PMo12O40 and H4PMo11VO40 as precursors. Four catalysts were prepared (PMo12C16, PMo11VC16, PMo12C16Py, and PMo11VC16Py) and characterized by P-31 NMR, FT-IR, XRD, SEM analysis and textural properties (S-BET). The acidic characteristics of the catalysts were determined by potentiometric titration with n-butylamine. A series of bioactive 1,4-dihydropyridine derivatives such as nifedipine and nemadipine B were synthesized using these new materials, in a one-pot procedure in ethanol. This methodology requires a reaction time of 8 h, and a temperature of 78 A degrees C to obtain good to excellent yields of 1,4-dihydropyridine derivatives. The micellar Keggin catalysts are insoluble in polar media, which allows easy removal of the reaction products without affecting their catalytic activity. The leaching test showed that they have an excellent stability and can be used five times as heterogeneous catalysts without appreciable loss of the catalytic activity. Using the same material, unsymmetrical 1,4-dihydropyridines such as nitrendipine can be obtained through a sequence of steps in very good yield (78 %).
机译：以十六烷基三甲基溴化铵（十六烷基三甲基溴化铵-CTAB）、1-十六烷基氯化吡啶和Keggin杂多酸H3PMo12O40和H4PMo11VO40为前驱体，制备了胶束Keggin杂多酸催化剂。制备了4种催化剂（PMo12C16、PMo11VC16、PMo12C16Py和PMo11VC16Py），并通过P-31 NMR、FT-IR、XRD、SEM分析和织构性能（S-BET）进行了表征。催化剂的酸性特性通过正丁胺的电位滴定法测定。使用这些新材料在乙醇中一锅法合成了一系列具有生物活性的1,4-二氢吡啶衍生物，如硝苯地平和奈马地平B。该方法需要8小时的反应时间和78 A的温度才能获得1,4-二氢吡啶衍生物的良好收率。胶束Keggin催化剂不溶于极性介质，因此可以很容易地去除反应产物，而不会影响其催化活性。浸出试验表明，它们具有优异的稳定性，可以作为非均相催化剂使用5次，而不会明显损失催化活性。使用相同的材料，可以通过一系列步骤获得不对称的1,4-二氢吡啶，如尼群地平，收率非常好（78%）。

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