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首页> 外文期刊>journal of cellular physiology >Polyene macrolide antibiotic cytotoxicity and membrane permeability alterations. II. Phenotypic expression in intraspecific and interspecific somatic cell hybrids
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Polyene macrolide antibiotic cytotoxicity and membrane permeability alterations. II. Phenotypic expression in intraspecific and interspecific somatic cell hybrids

机译：多烯大环内酯类抗生素的细胞毒性和膜通透性改变。II. 种内和种间体细胞杂交种的表型表达

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AbstractCytotoxicity and membrane permeability alterations induced by the polyene macrolide antibiotics filipin (FIL) and pimaricin (PIM) have been compared in parental intraspecific and interspecific somatic cell hybrids. B82 (mouse) and B1 (hamster) cells were found to be more resistant than RAG (mouse) parental cells to both polyene macrolides as indicated by 24‐hour survival, 72‐hour viability, and growth rate. Analysis of both intraspecific and interspecific somatic cell hybrids indicated that polyene macrolide resistance was being expressed even in the presence of the polyene macrolide‐sensitive (RAG) genome. Where one of the two parental cell types is relatively polyene macrolide resistant, the use of specific polyene macrolides may prove efficacious as half‐selective agents in cell hybrid
机译：摘要比较了多烯大环内酯类抗生素菲律宾（FIL）和匹马霉素（PIM）在亲本种内和种间体细胞杂交体中诱导的细胞毒性和膜通透性改变。发现 B82（小鼠）和 B1（仓鼠）细胞比 RAG（小鼠）亲本细胞对两种多烯大环内酯类药物的抗性更强，如 24 小时存活率、72 小时活力和生长速度所示。对种内和种间体细胞杂交体的分析表明，即使在多烯大环内酯敏感 （RAG） 基因组存在的情况下，多烯大环内酯类耐药性也表达出来。如果两种亲本细胞类型中的一种对多烯大环内酯类具有相对耐药性，则在细胞杂交中，使用特定的多烯大环内酯类药物作为半选择性试剂可能被证明是有效的

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