Analysis and validation of overall N‐glycan conformation in Privateer

Jordan S. Dialpuri; Haroldas Bagdonas; Mihaela AtanasovaLucy C. SchofieldMaarten L. HekkelmanRobbie P. JoostenJon Agirre

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Analysis and validation of overall N‐glycan conformation in Privateer

机译：Analysis and validation of overall N‐glycan conformation in Privateer

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摘要

The oligosaccharides in N‐glycosylation provide key structural and functional contributions to a glycoprotein. These contributions are dependent on the composition and overall conformation of the glycans. The Privateer software allows structural biologists to evaluate and improve the atomic structures of carbohydrates, including N‐glycans; this software has recently been extended to check glycan composition through the use of glycomics data. Here, a broadening of the scope of the software to analyse and validate the overall conformation of N‐glycans is presented, focusing on a newly compiled set of glycosidic linkage torsional preferences harvested from a curated set of glycoprotein models.

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《Acta crystallographica. Section D, Structural biology》 |2023年第6期|462-472|共11页
作者
Jordan S. Dialpuri; Haroldas Bagdonas; Mihaela AtanasovaLucy C. SchofieldMaarten L. HekkelmanRobbie P. JoostenJon Agirre;
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作者单位

York Structural Biology Laboratory, Department of Chemistry,University of York;

Oncode Institute and Division of Biochemistry,Netherlands Cancer Institute;

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原文格式 PDF
正文语种英语
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关键词
glycobiology; validation; Privateer; N‐glycans; torsion angles;

Analysis and validation of overall N‐glycan conformation in Privateer

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