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首页> 外文期刊>Infectious disorders drug targets >Biological Activities and Secondary Metabolite Screening of Rumex hastatus Extract through Fourier Transform Infrared and Raman Spectroscopy
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Biological Activities and Secondary Metabolite Screening of Rumex hastatus Extract through Fourier Transform Infrared and Raman Spectroscopy

机译：傅里叶变换红外光谱和拉曼光谱法对Rumex hastatus提取物的生物活性及次生代谢产物筛选

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Background: Human infectious diseases are caused by various pathogensincluding bacteria, fungi, viruses, parasites, and protozoans. These infectious agentsare controlled by using synthetic drugs as well as natural sources.Objective: The aim of current study was to evaluate the antibacterial effect of Rumexhastatus against clinical bacterial pathogens.Methods: In current research antibacterial effect of Rumex hastatus was analyzedagainst seven clinical pathogenic bacteria such as Escherichia coli, Serratia marcescens,Streptococcus pyogenes, Staphylococcus epidermidis, Staphylococcus aureus,Klebsiella pneumoniae and Pseudomonas aeruginosa through agar well diffusionmethod. The boiled extract was used for the phytochemical screening, antioxidantpotential, thin layer chromatography, bio-autography, and spot screening. GenomicDNA was extracted to find the DNA protection effect of R. hastatus.Results: Antibacterial results showed that diethyl ether extract has the maximum inhibitionof S. pyogenes (9.66 ± 0.57 mm). Acetone and diethyl ether extracts showedmoderate inhibition of K. pneumoniae (6.33 ± 1.52 mm and 5.66 ±1.15 mm) and S.aureus (6.33 ± 1.52 mm and 5.66 ± 0.57 mm). Similarly, chloroform extract indicatedmoderate inhibition of S. pyogenes (5.66 ± 1.15 mm). Ethanol extract had low oreven no effect on the growth of bacteria. Genomic DNA extraction also encouragedthe antibacterial effect of R. hastatus. Various phytochemical constituents such asketoses, oligosaccharides, amino acids, amines, sugars, flavonoids, and antioxidantconstituents were detected. TLC-Bioautography and spot screening results revealedthe potential use of R. hustatus as an antibacterial agent.Conclusion: It was concluded that most of the tested fractions appeared as an importantsource for the discovery of new antimicrobial drugs.

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