Glyco disulfide capped gold nanoparticle synthesis: cytotoxicity studies and effects on lung cancer A549 cells

Adokoh Christian K.; Keter Franklin K.; Obuah CollinsKinfe Henok H.Tshikhudo RobertDarkwa James

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Glyco disulfide capped gold nanoparticle synthesis: cytotoxicity studies and effects on lung cancer A549 cells

机译：糖基二硫键封端金纳米颗粒合成：细胞毒性研究及其对肺癌A549细胞的影响

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Background: Glyco disulfide gold nanoparticles (GDAuNPs) were prepared by three methods: direct, photochemical irradiation and ligand substitution. Glyco disulfide acted as reducing and capping agents of gold ions, to produce AuNP5 GD1-GD16. Results: Shorter chains of glyco disulfides (n = 1 and 2) offered monodispersed and stable GDAuNP5 in physiological pH, while longer chains (n = 3) furnished unstable nanoparticles. zeta-potential study of direct method GDAuNP5 revealed surface charge dependency on the alkyl unit length. Transmission electron microscope imaging indicated that sizes/shapes of the ligand exchange AuNP5 remained post-exchange step. The mechanism of GDAuNP formation was forecast as the Ostwald ripening effect at low pH of ligand (5.1-8.9) and reinforcement of static stabilization at high pH (12.4-13.0). Conclusion: GDAuNP5 recorded moderately anticancer activity against the A549 cancer cell line, with IC50 between 14.95 and 64.95 mu g/ml.

机译：背景：采用直接、光化学辐照和配体取代三种方法制备了糖二硫化金纳米颗粒（GDAuNPs）。糖二硫化物作为金离子的还原剂和封端剂，生成AuNP5 GD1-GD16。结果：较短的糖二硫化物链（n = 1和2）在生理pH值下提供单分散和稳定的GDAuNP5，而较长的链（n = 3）提供不稳定的纳米颗粒。直接法GDAuNP5的zeta电位研究表明，表面电荷与烷基单元长度有关。透射电子显微镜成像表明，配体交换AuNP5的大小/形状在交换后仍保留。GDAuNP的形成机制被预测为配体低pH值（5.1-8.9）下的Ostwald成熟效应和高pH值（12.4-13.0）静态稳定性的增强。结论：GDAuNP5对A549癌细胞系具有中等抗癌活性，IC50在14.95-64.95 μg/ml之间。

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《Future medicinal chemistry》 |2022年第5期|307-324|共18页
作者
Adokoh Christian K.; Keter Franklin K.; Obuah CollinsKinfe Henok H.Tshikhudo RobertDarkwa James;
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作者单位

Dept Chem Sci,Univ Johannesburg;

Adv Mat Div,Mintek;

Dept Chem,Univ Ghana;

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原文格式 PDF
正文语种英语
中图分类药学;
关键词
amino alkyl thiol; anticancer; D-(+)-gluconic acid delta-lactone; glyco disulfide; glyco nanoparticles; SELF-ASSEMBLED MONOLAYERS; ENHANCED RAMAN-SPECTROSCOPY; LIGAND-EXCHANGE; CITRATE; GLYCONANOPARTICLES; AU; ABSORPTION; REDUCTION; MECHANISM; SPECTRA;

机译：氨基烷基硫醇;抗癌;D-（+）-葡萄糖酸 δ-内酯;二硫醚糖;糖纳米颗粒;自组装单层膜;增强型拉曼光谱;配体交换;枸橼酸盐;糖基颗粒;AU;吸收;减少;机制;光谱;

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Glyco disulfide capped gold nanoparticle synthesis: cytotoxicity studies and effects on lung cancer A549 cells

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