Improving Cancer Vaccine Efficiency by Nanomedicine

Cai Junyu; Wang Hao; Wang DanggeLi Yaping

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Improving Cancer Vaccine Efficiency by Nanomedicine

机译：Improving Cancer Vaccine Efficiency by Nanomedicine

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Abstract Cancer vaccines, which have been widely investigated in the past few decades, are one of the most attractive strategies for cancer immunotherapy. Through the precise delivery of antigens and adjuvants to lymphoid organs or lymphocytes via nanotechnology, innate and adaptive immunity can be boosted to prevent the growth and relapse of malignant tumors. Indeed, nanomedicine offers great opportunities to improve the efficiency of vaccines. Various functional platforms are used to deliver small molecules, peptides, nucleic acids, and even whole cell antigens to the target area of interest, achieving enhanced antitumor immunity and durable therapeutic benefits. Herein, the recent progress in cancer vaccines based on nanotechnology is summarized. Novel platforms used for delivering tumor antigens, promoting adjuvant functions, and combining other therapeutic strategies are discussed. Moreover, possible striving directions and major challenges of nanomedicine for vaccination are also reviewed.

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来源
《Advanced Biosystems》 |2019年第3期|n/a-n/a|共18页
作者
Cai Junyu; Wang Hao; Wang DanggeLi Yaping;
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作者单位

China State Institute of Pharmaceutical Industry285 Gebaini Road,201203,Shanghai,China;

State Key Laboratory of Drug Research and Center of PharmaceuticsChinese Academy of Sciences501 Haike Road,201203,Shanghai,China;

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原文格式 PDF
正文语种英语
中图分类生物科学;
关键词
adjuvants; cancer immunotherapy; cancer vaccines; delivery systems; nanomedicine;

Improving Cancer Vaccine Efficiency by Nanomedicine

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