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首页> 外文期刊>Obstetrics and Gynecology: Journal of the American College of Obstetricians and Gynecologists >Prognostic significance of tumor angiogenesis in endometrial cancer.
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Prognostic significance of tumor angiogenesis in endometrial cancer.

机译：子宫内膜癌肿瘤血管生成的预后意义。

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OBJECTIVE: To determine the prognostic effect of intratumor microvessel density in a series of unselected patients with endometrial carcinoma. METHODS: We reviewed 93 consecutive patients treated surgically for endometrial cancer at the University Hospital of Vienna between 1983 and 1989. Histologic sections were obtained from original paraffin-embedded blocks and stained immunohistochemically for CD34 antigen. Microvessel density was determined by enumeration of intratumor CD34-positive cells under a light microscope at 200 x magnification using an examination area of 0.74 mm2. Log-rank test and Cox proportional-hazards models (univariate and multivariate) were applied for overall survival analysis. RESULTS: Overall, the 25% quantile of survival was reached at 37.9 months. The 5-year survival rate was 82.2% in 69 patients whose tumors had microvessel counts no more than 100/0.74 mm2 field, and 52.0% in 24 patients whose tumors had microvessel counts of more than 100/0.74 mm2 field (log-rank P = .004). In the multiple Cox model, high microvessel counts (relative risk [RR] 1.2; 95% confidence interval [CI] 1.1, 1.4) as well as undifferentiated tumors (RR 6.1; CI 2.2, 16.8), and advanced stage of disease (RR 2.6; CI 1.3, 5.1) independently exerted an adverse influence on the survival of patients with endometrial cancer. CONCLUSION: High intratumor microvessel count is associated with poor survival of patients with endometrial cancer.
机译：目的：探讨肿瘤内微血管密度对一系列未经选择的子宫内膜癌患者的预后影响。方法： 我们回顾了 1983 年至 1989 年间在维也纳大学医院接受子宫内膜癌手术治疗的 93 例连续患者。从原始石蜡包埋的块中获得组织学切片，并对 CD34 抗原进行免疫组织化学染色。通过使用 0.74 mm2 的检查区域在 200 倍放大倍率的光学显微镜下计数肿瘤内 CD34 阳性细胞来确定微血管密度。采用Log-rank检验和Cox比例风险模型（单因素和多因素）进行总生存期分析。结果：总体而言，在 37.9 个月时达到 25% 的生存分位数。69例肿瘤微血管计数不超过100/0.74 mm2视野的患者的5年生存率为82.2%，24例肿瘤微血管计数大于100/0.74 mm2视野的患者的5年生存率为52.0%（log-rank P = .004）。在多重 Cox 模型中，高微血管计数（相对危险度 [RR] 1.2;95% 置信区间 [CI] 1.1,1.4）以及未分化肿瘤（RR 6.1;CI 2.2， 16.8）和疾病晚期（RR 2.6;CI 1.3， 5.1）独立地对子宫内膜癌患者的生存率产生不利影响。结论：肿瘤内微血管计数高与子宫内膜癌患者生存率低有关。

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