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首页> 外文期刊>Infectious disorders drug targets >Evaluation of Antibiotic Susceptibility Pattern and Distribution of coa Genes in Coagulase-negative S. aureus from Ahvaz, Iran
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Evaluation of Antibiotic Susceptibility Pattern and Distribution of coa Genes in Coagulase-negative S. aureus from Ahvaz, Iran

机译：伊朗阿瓦士凝固酶阴性金黄色葡萄球菌中抗生素敏感模式和coa基因分布的评价

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Background: Staphylococcus aureus is one of the important causes of clinical infections that can be more destructive by its antibiotic resistant strains.Objective: This study aimed to determine the antibiotic susceptibility pattern and distribution of mecA and coa genes in clinical isolates of S. aureus. Methods: Two hundred seventy-three specimens suspected to S. aureus were taken from hospitals of Ahvaz, southwest of Iran. Isolates were identified by standard microbiologic tests and confirmed by the molecular method. Antimicrobial susceptibility testing was carried out by disk diffusion method. The presence of mecA and coa genes was determined by PCR method. Results: Of a total of 200 isolates which were tested for coagulase tube test, 143 (71.5%) showed coagulase positive, and 57 (28.5%) showed a coagulase-negative reaction. Antibacterial susceptibility pattern of 200 S. aureus isolates showed the highest and lowest susceptibility rate to line-zolid (98%) and ciprofloxacin (42%), respectively. The prevalence of methicillin-resistant S. aureus (MRS A) by detection of mecA gene was estimated as 47.5 % (95/200), of which the rate of MRSA in coagulase positive and negative isolates was 35% (50/143), and 65% (45/57), respectively. Meanwhile, coa gene was detected in 100% of coagulase positive and 28.1% of coagulase-negative isolates. Conclusion: The results of this study showed that the number of atypical CNSA in our area is high. Since the coagulase test is an essential test for diagnosis of S. aureus, our findings regarding the emergence of CNSA are a warning about the misdiagnosis and selection of appropriate treatment approach for S. aureus isolates.
机译：背景：金黄色葡萄球菌是临床感染的重要原因之一，其抗生素耐药菌株可能更具破坏性。目的：探讨临床分离株金黄色葡萄球菌mecA和coa基因的药敏模式及分布。方法：从伊朗西南部阿瓦士的医院采集了273个疑似金黄色葡萄球菌的标本。通过标准微生物学测试鉴定分离株，并通过分子方法确认。采用圆盘扩散法进行药敏试验。通过PCR方法测定mecA和coa基因的存在。结果：共200株菌株进行凝固酶管试验，其中143株（71.5%）为凝固酶阳性，57株（28.5%）为凝固酶阴性反应。200株金黄色葡萄球菌分离株的抗菌药敏模式对利唑胺（98%）和环丙沙星（42%）的药敏率分别最高和最低。mecA基因检测耐甲氧西林金黄色葡萄球菌（MRS A）的患病率估计为47.5%（95/200），其中凝固酶阳性和阴性分离株中MRSA的发生率分别为35%（50/143）和65%（45/57）。同时，在100%的凝固酶阳性和28.1%的凝固酶阴性分离株中检测到coa基因。结论： 本研究结果表明，本地区非典型CNSA数量较高。由于凝固酶试验是诊断金黄色葡萄球菌的重要试验，因此我们关于CNSA出现的发现是对金黄色葡萄球菌分离株的误诊和适当治疗方法选择的警告。

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