Molecular Imprinted Polymer Modified Electrochemical Sensors for Small Drug Analysis: Progress to Practical Application

Feroz Momina; Vadgama Pankaj

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Molecular Imprinted Polymer Modified Electrochemical Sensors for Small Drug Analysis: Progress to Practical Application

机译：用于小药分析的分子印迹聚合物改性电化学传感器：实际应用进展

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Molecular imprinted polymers (MIPs) are tailor made from synthetic polymers and designed to mimic the recognition properties of natural biological affinity molecules. MIPs incorporate binding motifs complementary to target organic molecule shape and functional groups in order to mimic the complex binding surfaces of natural macromolecules. This confers selectivity and specificity, with the added advantage of artificial MIP polymer stability and ready adaptability to the fabrication and creation of miniaturised affinity interfaces for electrochemical sensing and extra-laboratory testing. Their generic capability as robust sorbent phases for drug extraction and concentration allows for targeted, interfacial interrogation by the active electrochemical surface. A wide range of electrochemical sensing strategies has also been advanced in recent years, which is covered by this review. The review covers MIP functional principles, examples of MIP preparative routes and final assay outcomes for the measurement of small molecule drugs of biomedical, and also of potential environmental relevance. Some small molecules as examples of toxin and contaminant measurement are also given. A historic background to MIP development is provided, but the review mainly focuses on electrochemical sensor advances in the last five years.

机译：分子印迹聚合物（MIP）由合成聚合物量身定制，旨在模拟天然生物亲和分子的识别特性。MIPs结合了与靶向有机分子形状和官能团互补的结合基序，以模拟天然大分子的复杂结合表面。这赋予了选择性和特异性，并具有人工MIP聚合物稳定性的额外优势，以及用于电化学传感和实验室外测试的小型亲和界面的制造和创建。它们作为用于药物提取和浓缩的稳健吸附剂相的通用能力允许通过活性电化学表面进行有针对性的界面询问。近年来，电化学传感策略也得到了广泛的发展，本文对此进行了综述。该综述涵盖了MIP的功能原理、MIP制备途径的例子和用于测量生物医学小分子药物的最终测定结果，以及潜在的环境相关性。还给出了一些小分子作为毒素和污染物测量的例子。本文介绍了MIP发展的历史背景，但本文主要关注过去五年电化学传感器的进展。

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来源
《Electroanalysis》 |2020年第11期|2361-2386|共26页
作者
Feroz Momina; Vadgama Pankaj;
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作者单位

Univ Punjab, Inst Chem, Lahore 54590, Pakistan;

Queen Mary Univ London, Sch Engn & Mat Sci, Mile End Rd, London E1 4NS, England;

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原文格式 PDF
正文语种英语
中图分类电化学、电解、磁化学;
关键词
Molecular Imprinted Polymers; Electrochemical Sensing; Electropolymerization; Voltammetric Sensors; Potentiometric Sensors; Drugs; Environmental Drug Contamination;

机译：分子印迹聚合物;电化学传感;电聚合;伏安传感器;电位传感器;药品;环境药物污染;

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Molecular Imprinted Polymer Modified Electrochemical Sensors for Small Drug Analysis: Progress to Practical Application

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