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Phthalocyanine-based photoacoustic contrast agents for imaging and theranostics

机译：用于成像和治疗诊断学的酞菁基光声造影剂

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Phthalocyanine, as an organic dye, has attracted much attention due to its high molar absorption coefficient in the near-infrared region (NIR). It is precisely because of this advantage that phthalocyanine is very beneficial to photoacoustic imaging (PAI). At present, many different strategies have been adopted to design phthalocyanine-based contrast agents with photoacoustic (PA) effect, including increasing water solubility, changing spectral properties, prolonging the circulation time, constructing activatable supramolecular nanoparticles, increasing targeting, etc. Based on this, this minireview highlighted the above ways to enhance the PA effect of phthalocyanine. What's more, the application of phthalocyanine-based PA contrast agents in biomedical imaging and image-guided phototherapy has been discussed. Finally, this minireview also provides the prospects and challenges of phthalocyanine-based PA contrast agents in order to provide some reference for the application of phthalocyanine-based PA contrast agents in biomedical imaging and guiding tumor treatment.
机译：酞菁作为一种有机染料，因其在近红外区（NIR）的高摩尔吸收系数而备受关注。正是由于这一优点，酞菁对光声成像（PAI）非常有利。目前，已经采用了许多不同的策略来设计具有光声效应的酞菁基造影剂，包括提高水溶性、改变光谱性质、延长循环时间、构建可激活的超分子纳米颗粒、增加靶向性等。基于此，本小型综述重点介绍了上述增强酞菁PA效应的方法。此外，还讨论了基于酞菁的PA造影剂在生物医学成像和图像引导光疗中的应用。最后，本文还对酞菁类PA造影剂的前景和挑战进行了展望和挑战，以期为酞菁类PA造影剂在生物医学成像和肿瘤治疗中的应用提供一定的参考。

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