Mortality from herpes simplex virus (HSV) infection in Australian children, 1999-2011 using national datasets

KhandakerG.; Raynes-GreenowC.; Smithers-SheedyH.BooyR.MenziesR.JonesC.

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Mortality from herpes simplex virus (HSV) infection in Australian children, 1999-2011 using national datasets

机译：Mortality from herpes simplex virus (HSV) infection in Australian children, 1999-2011 using national datasets

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Background: This study examines national childhood HSV mortality data in Australia from 1999-2011. This information is important to better understand the disease burden of HSV in early life and to formulate public health interventions.Methods: Retrospective analysis of Australian Bureau of Statistics (ABS) national mortality data from 1999- 2011 in children aged <15 years who died with specific ICD-10 codes for HSV infection listed as an underlying or contributing cause.Results: Twenty nine HSV-associated deaths in children aged <15 years from 1999-2011 were identified (0.05 per 100,000 children; 95% CI 0.04-0.06), 16 in the first month of life (0.45 per 100,000 live births; 95% CI 0.23- 0.67). Among those, 20 were males and 9 were females (p=0.04). The majority of deaths (69%) occurred in infants aged <12 months and most in infants aged <1 month (55%). HSV-associated death in infants aged < 1 month of age accounted for 0.15% of all neonatal deaths for 1999-2011 in Australia. A downward trend in HSV-associated neonatal mortality was observed between 1999 and 2011 (p=0.52). During the study period, mortality from HSV infections in Australian children resulted in an estimated 2,275 age-adjusted years of potential life lost.Conclusions: This data confirms reported findings from active surveillance of a downward trend in mortality rate from HSV infection in infants aged < 1 month in Australia over this period. Ongoing surveillance is required to confirm this observation.

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《Infectious disorders drug targets》 |2014年第2期|89-92|共4页
作者
KhandakerG.; Raynes-GreenowC.; Smithers-SheedyH.BooyR.MenziesR.JonesC.;
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Centre for Perinatal Infection Research, The Children’s Hospital at Westmead and The University of;

Marie Bashir Institute for Infectious Diseases and Biosecurity, The University of SydneySydney, NSW;

National Centre for Immunisation Research and Surveillance (NCIRS), The Children’s Hospital at;

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正文语种英语
中图分类药学;
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Children; Herpes simplex virus (HSV); Mortality; Neonate;

Mortality from herpes simplex virus (HSV) infection in Australian children, 1999-2011 using national datasets

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