Effects of Micro RNAs and their Targets in Periodontal Diseases

Samane Bourbour; Maryam Beheshti; Hossein KazemianAbbas Bahador

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Effects of Micro RNAs and their Targets in Periodontal Diseases

机译：Effects of Micro RNAs and their Targets in Periodontal Diseases

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摘要

RNA interference (RNAi) or Post-Transcriptional Gene Silencing is astrong mechanism of gene silencing which is moderated by MicroRNAs (miRNAs),underlying many fields of eukaryotic biology. The miRNAs are small noncodingRNAs and a gene regulation expression system which showing a tissue-specific expressionpattern, and inhibits protein synthesis. For the first time, miRNA has beenseen in Caenorhabditis elegans. They play an important role in signaling pathwaysof various diseases especially periodontal disease during periodontal inflammationand oral cancers. The most important miRNAs in periodontal diseases and oralsquamous cell carcinoma are miR-142-3p, miR-146a, miR-155, miR-203, and miR-223. One of the most important diseases in association with gingival infectious isperiodontal diseases which if left untreated, would lead to tooth loss. Hence, the aimof the present study is to focus the effects of miRNAs and their targets in diseaseswhich are mentioned above.

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来源
《Infectious disorders drug targets》 |2018年第3期|183-191|共9页
作者
Samane Bourbour; Maryam Beheshti; Hossein KazemianAbbas Bahador;
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作者单位

Department of Medical Microbiology, School of Medicine, Tehran University of Medical Sciences;

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原文格式 PDF
正文语种英语
中图分类药学;
关键词
MicroRNA; MicroRNA regulation expression; Biomarkers; Periodontal diseases; Porphyromonasgingivalis; Photodynamic therapy;

Effects of Micro RNAs and their Targets in Periodontal Diseases

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