Study of Different Carbonaceous Materials as Modifiers of Screen‐printed Carbon Electrodes for the Triazid as Potential Antiviral Drug

Alexandra Ivoilova; Nataliya Malakhova; Polina MozharovskaiaAlexandra NikiforovaAndrey TumashovAlisa KozitsinaAlla IvanovaVladimir Rusinov

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Study of Different Carbonaceous Materials as Modifiers of Screen‐printed Carbon Electrodes for the Triazid as Potential Antiviral Drug

机译：Study of Different Carbonaceous Materials as Modifiers of Screen‐printed Carbon Electrodes for the Triazid as Potential Antiviral Drug

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Abstract In this work a comparative study of Screen‐Printed Carbon Electrodes (SPCE) – bare and modified by drop casting with carbonaceous nanomaterials (CNMs) as Multi Walled Carbon Nanotubes (MWCNT), Carbon Black and Functionalized Carbon Black for voltammetric determination of 5‐methyl‐6‐nitro‐7‐oxo‐4,7‐dihydro‐1,2,4‐triazolo[1,5‐a]pyrimidinide l‐arginine monohydrate (Triazid) as a potential drug with a broad spectrum of antiviral activity is reported. Bare SPCE and CNMs modified SPCE (SPCE/CNMs) have been characterized morphologically by SEM and electrochemically by cyclic voltammetry/electrochemical impedance spectroscopy with [Fe(CN)6]4−/3− as redox probe. Significant improvement of electrochemical performances is achieved with SPCE/CNMs compared with the bare SPCE. Among SPCE/CNMs studied SPCE modified with MWCNT (SPCE/CNT) is characterized by the best combination of electrochemical properties and electroanalytical performance towards TD. The linear dynamic range is 25–200 mg L−1 (R2=0.9975) with the limit of detection – 2.8 mg L−1 Triazid using SPCE/CNT and Square‐Wave Voltammetry technique. The developed sensor was successfully used for Triazid determination in the Pharmaceutical Substance “TRIAZID”. The results achieved with SPCE/CNMs after chemical binding of dissolved oxygen in 0.04 M Britton‐Robinson buffer+0.04 M Na2SO3 (pH 7.2±0.2) are very useful for further development of cost‐effective and time‐consuming pharmaceutical routine assay.

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《Electroanalysis》 |2022年第11期|1745-1755|共11页
作者
Alexandra Ivoilova; Nataliya Malakhova; Polina MozharovskaiaAlexandra NikiforovaAndrey TumashovAlisa KozitsinaAlla IvanovaVladimir Rusinov;
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作者单位

Ural Federal University;

Russian Academy of Sciences;

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正文语种英语
中图分类电化学、电解、磁化学;
关键词
Screen-printed carbon electrode; Carbon black; Carbon nanotubes; Nitro-1; 2; 4-triazolo1; 5-apyrimidines; Triazid;

Study of Different Carbonaceous Materials as Modifiers of Screen‐printed Carbon Electrodes for the Triazid as Potential Antiviral Drug

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