Transition state analogue inhibitors of protozoan nucleoside hydrolases.

Furneaux RH; Schramm VL; Tyler PC

首页> 外文期刊>Bioorganic and medicinal chemistry >Transition state analogue inhibitors of protozoan nucleoside hydrolases.

【24h】

Transition state analogue inhibitors of protozoan nucleoside hydrolases.

机译：Transition state analogue inhibitors of protozoan nucleoside hydrolases.

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相关主题

摘要

Protozoan parasites are unable to synthesize purines de novo and must rely on purine salvage pathways for their requirements. Nucleoside hydrolases, which are not found in mammals, function as key enzymes in purine salvage in protozoa. Inhibition of these enzymes may disrupt purine supply and specific inhibitors are potential therapeutic agents for the control of protozoan infections. A series of 1,4-dideoxy-1,4-imino-D-ribitols bearing C-bonded aromatic substituents at C-1 have been synthesized, following carbanion additions to the imine 2, and tested as potential nucleoside hydrolase inhibitors. Nucleoside analogues 8, 11, 14, 17, 20, 24-26, 28 exhibit Ki values in the range 0.2-22 microM against two representative isozymes of protozoan nucleoside hydrolases.

著录项

来源
《Bioorganic and medicinal chemistry》 |1999年第11期|2599-2606|共8页
作者
Furneaux RH; Schramm VL; Tyler PC;
展开▼
作者单位

Carbohydrate Chemistry, Industrial Research Limited, Lower Hutt, New Zealand.;

展开▼
收录信息
原文格式 PDF
正文语种英语
中图分类药学;生物化学;
关键词
Enzyme Inhibitors; Nucleosidases; inosine adenosine guanosine preferring nucleoside hydrolase; 酶抑制剂; 核苷酶类;

Transition state analogue inhibitors of protozoan nucleoside hydrolases.

摘要

著录项

相关主题

期刊订阅