Candida albicansandTorulopsis glabrataare the most prevalent yeasts in humans. The majority harborC. albicansin the oral cavity, but only a few develop oral candidiasis. We have sought a possible relationship between indigenous salivary constituents, including antimicrobial and nutritive factors, and the growth rate and/or viability of inoculated fungi in glucose‐supplemented sterilized saliva. Stimulated whole saliva was collected from 30 healthy donors. Saliva samples were sterilized, supplemented with glucose and inoculated withC. albicansorT. glabrata. After incubation of the inoculates for 20 h, the number of viable cells were counted. All saliva samples were analyzed for different indigenous salivary components andCandidabefore as well as after sterilization. Besides a 4% reduction in calcium (Ca2+) and thiocyanate (SCN−) concentrations, sterilization did not affect the concentrations of saliva electrolytes, but the proteins were significantly reduced (19–85%). Indigenous candidal carriage (n=19) correlated with neither the growth of inoculated fungi nor any of the analyzed components in saliva. The growth ofC. albicansandT. glabratawas similar at pH 5 but, at pH 6,C. albicanshad a remarkably slower growth rate thanT. glabrata. Statistical analysis showed that the 5‐h growth ofC. albicansat pH 5 was associated with water and electrolyte secretion, whereas the growth after 20 h was associated with variations in protein‐glycoprotein content. The growth ofT. glabratawas not related to variations in the salivary variables
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