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首页> 外文期刊>Infectious disorders drug targets >Current Updates on Role of Lipids in Hematopoiesis
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Current Updates on Role of Lipids in Hematopoiesis

机译：Current Updates on Role of Lipids in Hematopoiesis

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Hematopoiesis is the process which generates all the mature blood cellsfrom the rare pool of Hematopoietic stem cells (HSCs). Asymmetric cell division ofHSCs provide it dual capacity for self-renewal and multi-potent differentiation.Hematopoiesis is a steady state process in which mature blood cells are produced atthe same rate at which they are lost, establishing a homeostasis. HSCs are regulatedthrough their environmental niche, cytokine signalling, and the orchestrated activitiesof various transcription factors. However, there is very little information availableabout the signal transduction events that regulate HSC function; in particular, the effectsof bioactive lipids and lipid mediators are not well understood. Recent studieshave added an important aspect of this process, introducing the role of lipids in cellfate decisions during hematopoiesis. The mechanisms of bioactive lipids and theirderivatives have been studied extensively in signal transduction and various othercellular processes.This review focuses on various categories of lipids and their regulatory mechanismsin HSCs and their comment into different blood cells. Moreover, we also discuss therole of lipid signalling specifically in megakaryocyte and platelets.

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